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Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7
- Source :
- BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE(16), BMC Complementary and Alternative Medicine
- Publisher :
- Springer Nature
-
Abstract
- Background: Hominis Placenta (HP) known as a restorative medicine in Traditional Chinese Medicine (TCM), has been widely applied in the clinics of Korea and China as an anti-aging agent to enhance the regeneration of tissue. This study was conducted to investigate whether topical treatment of HP promotes hair regrowth in the animal model. Methods: The dorsal hairs of 8-week-old C57BL/6 mice were depilated to synchronize hair follicles to the anagen phase. HP was applied topically once a day for 15 days. Hair growth was evaluated visually and microscopically. The incorporation of bromodeoxyuridine (BrdU) and expression of proliferating cell nuclear antigen (PCNA), fibroblast growth factor-7 (FGF-7) in dorsal skin tissue was examined by immunohistochemical analysis. Reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of FGF-7. Results: HP exhibited potent hair growth-promoting activity in C57BL/6 mice. Gross examination indicated that HP markedly increased hair regrowth as well as hair density and diameter. Histologic analysis showed that HP treatment enhanced the anagen induction of hair follicles. Immunohistochemical analysis revealed that BrdU incorporation and the expressions of PCNA were increased by treatment of HP. HP treatment significantly increased the expression of FGF-7, which plays pivotal roles to maintain anagen phase both protein and mRNA levels. Conclusions: Taken together, our results indicate that HP has a potent hair growth-promoting activity; therefore, it may be a good candidate for the treatment of alopecia.
- Subjects :
- Male
0301 basic medicine
Fibroblast Growth Factor 7
Hair growth
Placenta
Fibroblast growth factor-7
Andrology
Mice
030207 dermatology & venereal diseases
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pregnancy
Hominis Placenta
Anagen
Bromodeoxyuridine
Fibroblastgrowth factor-7
medicine
Animals
Humans
Medicine, Chinese Traditional
Fibroblast
Cell Proliferation
Back
Biological Products
biology
integumentary system
Cell growth
business.industry
General Medicine
Hair follicle
Proliferating cell nuclear antigen
Mice, Inbred C57BL
Reverse transcription polymerase chain reaction
030104 developmental biology
medicine.anatomical_structure
chemistry
Complementary and alternative medicine
Immunology
biology.protein
Female
business
Hair Follicle
Research Article
Hair
Subjects
Details
- Language :
- English
- ISSN :
- 14726882
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Complementary and Alternative Medicine
- Accession number :
- edsair.doi.dedup.....2b1c5f3b8dd655d6da246676f9db33b8
- Full Text :
- https://doi.org/10.1186/s12906-016-1180-3