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A developmental reduction of the excitation:inhibition ratio in association cortex during adolescence
- Source :
- Science advances. 8(5)
- Publication Year :
- 2022
-
Abstract
- Adolescence is hypothesized to be a critical period for the development of association cortex. A reduction of the excitation:inhibition (E:I) ratio is a hallmark of critical period development; however it has been unclear how to assess the development of the E:I ratio using non-invasive neuroimaging techniques. Here, we used pharmacological fMRI with a GABAergic benzodiazepine challenge to empirically generate a model of E:I ratio based on multivariate patterns of functional connectivity. In an independent sample of 879 youth (ages 8-22 years), this model predicted reductions in the E:I ratio during adolescence, which were specific to association cortex and related to psychopathology. These findings support hypothesized shifts in E:I balance of association cortices during a neurodevelopmental critical period in adolescence.TeaserInhibitory maturation of the association cortex reflects an adolescent critical period.
- Subjects :
- Adult
Cerebral Cortex
Multidisciplinary
Adolescent
Functional connectivity
Period (gene)
Excitation inhibition
Neuroimaging
Biology
Magnetic Resonance Imaging
Young Adult
medicine.anatomical_structure
Cortex (anatomy)
medicine
GABAergic
Humans
Association (psychology)
Child
Neuroscience
Psychopathology
Subjects
Details
- ISSN :
- 23752548
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Science advances
- Accession number :
- edsair.doi.dedup.....2b18ffbcaa534a14467033e026b3175a