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Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses
- Source :
- Pharmacogenomics. 18(5)
- Publication Year :
- 2017
-
Abstract
- Aim: To replicate the genome-wide associations of the antihypertensive effects of bisoprolol and losartan in GENRES, using the Finnish patients of LIFE study. Patients & methods: We analyzed association of four SNPs with atenolol and three SNPs with losartan response in 927 Finnish LIFE patients (467 for atenolol and 460 for losartan). Results: rs2514036, a variation at a transcription start site of ACY3, was associated with blood pressure response to atenolol in men in LIFE. Response to bisoprolol was correlated to baseline plasma levels of N-acetylphenylalanine and phenylalanine (ACY3 substrate and end product, respectively) in GENRES study. NPHS1 variation rs3814995 was associated with losartan effect in LIFE. Conclusion: We provide support for two pharmacogenomic markers for beta-blockers and angiotensin receptor antagonists.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
medicine.drug_class
education
Single-nucleotide polymorphism
Blood Pressure
Pharmacology
Polymorphism, Single Nucleotide
Amidohydrolases
03 medical and health sciences
Double-Blind Method
Predictive Value of Tests
Internal medicine
Genetics
medicine
Humans
Prospective Studies
Antihypertensive drug
Antihypertensive Agents
Finland
Aged
Aged, 80 and over
Angiotensin Receptor Antagonists
Cross-Over Studies
business.industry
Genetic Variation
Membrane Proteins
Middle Aged
Atenolol
3. Good health
030104 developmental biology
Endocrinology
Blood pressure
Losartan
Treatment Outcome
Bisoprolol
317 Pharmacy
Pharmacogenomics
Molecular Medicine
business
circulatory and respiratory physiology
medicine.drug
Subjects
Details
- ISSN :
- 17448042
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Pharmacogenomics
- Accession number :
- edsair.doi.dedup.....2b119112d4eff0add8121c35c299896c