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Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The pathogenesis of ME/CFS, a disease characterized by fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, irritable bowel syndrome (IBS), and lymphadenopathy, is poorly understood. We report biomarker discovery and topological analysis of plasma metabolomic, fecal bacterial metagenomic, and clinical data from 50 ME/CFS patients and 50 healthy controls. We confirm reports of altered plasma levels of choline, carnitine and complex lipid metabolites and demonstrate that patients with ME/CFS and IBS have increased plasma levels of ceramide. Integration of fecal metagenomic and plasma metabolomic data resulted in a stronger predictive model of ME/CFS (cross-validated AUC = 0.836) than either metagenomic (cross-validated AUC = 0.745) or metabolomic (cross-validated AUC = 0.820) analysis alone. Our findings may provide insights into the pathogenesis of ME/CFS and its subtypes and suggest pathways for the development of diagnostic and therapeutic strategies.
- Subjects :
- Male
Sleep Wake Disorders
0301 basic medicine
lcsh:Medicine
Orthostatic intolerance
Disease
Article
Irritable Bowel Syndrome
Pathogenesis
Feces
03 medical and health sciences
Metabolomics
medicine
Chronic fatigue syndrome
Humans
Biomarker discovery
lcsh:Science
Fatigue
Irritable bowel syndrome
Fatigue Syndrome, Chronic
Multidisciplinary
business.industry
lcsh:R
Case-control study
Middle Aged
medicine.disease
3. Good health
Phenotype
030104 developmental biology
Case-Control Studies
Immunology
Female
lcsh:Q
Metagenomics
business
Biomarkers
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....2b046da50f4bc2a484c36f01bd120d74