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Mechanical workload-myocardial water content relationship in isolated rat hearts
- Source :
- American Journal of Physiology-Heart and Circulatory Physiology. 273:H271-H278
- Publication Year :
- 1997
- Publisher :
- American Physiological Society, 1997.
-
Abstract
- We tested the hypothesis that the mechanical workload of the heart inversely determines the rate of myocardial edema formation in an isolated, perfused rat heart preparation. Heart rate (HR) was varied in three groups by pacing at 125 (HR125), 250 (HR250), or 350 beats/min (HR350). Left ventricular pressure (LVP) was varied in two additional groups by pacing at 250 beats/min and with the addition of either epinephrine (Epi) or propranolol (Pro) to the perfusate. In five otherwise identical groups, variation of coronary vascular resistance was minimized by adenosine. Myocardial water content (MWC) varied significantly and inversely with HR in the HR125, HR250, and HR350 groups. MWC of the HR250 group was significantly less than that of the Pro group but did not differ from the Epi group. However, when adenosine was used, MWC had significant inverse relationships with HR and LVP. We concluded that the mechanical workload of the heart inversely determines the rate and degree of myocardial edema formation in this isolated heart preparation, and both HR and LVP are determinants of this relationship.
- Subjects :
- Male
Isolated Heart Preparation
medicine.medical_specialty
Adenosine
Epinephrine
Physiology
Hydrostatic pressure
Hemodynamics
Propranolol
In Vitro Techniques
Ventricular Function, Left
Rats, Sprague-Dawley
Body Water
Heart Rate
Physiology (medical)
Internal medicine
Heart rate
medicine
Animals
Edema
business.industry
Myocardium
Heart
Coronary Vessels
Rats
Endocrinology
medicine.anatomical_structure
Circulatory system
Ventricular pressure
Vascular resistance
Regression Analysis
Vascular Resistance
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 15221539 and 03636135
- Volume :
- 273
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Heart and Circulatory Physiology
- Accession number :
- edsair.doi.dedup.....2b04095f60327bae39c609fcd678ec2f
- Full Text :
- https://doi.org/10.1152/ajpheart.1997.273.1.h271