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Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands
- Source :
- Journal of NeuroVirology, 20(4), 412-418. Taylor & Francis Ltd
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Prevalence of eight human herpesviruses (HHV1-8) was determined by real-time PCR in cell-rich cerebrospinal fluid (CSF) samples, obtained early after disease symptoms, of Dutch patients with multiple sclerosis (MS) and other noninfectious central nervous system diseases (NIND). Whereas HHV1-8 DNA was undetectable in CSF samples of MS patients, HHV6 DNA was detected in a plexus neuritis case and HHV7 DNA in an ependymoma and a Behccts' disease patient. However, intrathecal HHV infection was not detected. Data indicate that HHV1-8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS.
- Subjects :
- Adult
Male
Ependymoma
medicine.medical_specialty
Pathology
Multiple Sclerosis
Neurology
Neuritis
Disease
Real-Time Polymerase Chain Reaction
medicine.disease_cause
Herpesviridae
Cellular and Molecular Neuroscience
Herpesviridae Infections
Cerebrospinal fluid
SDG 3 - Good Health and Well-being
Virology
Prevalence
medicine
Humans
Netherlands
business.industry
Multiple sclerosis
Middle Aged
medicine.disease
DNA, Viral
Immunology
Female
Neurology (clinical)
Nervous System Diseases
business
Subjects
Details
- ISSN :
- 15382443 and 13550284
- Database :
- OpenAIRE
- Journal :
- Journal of NeuroVirology
- Accession number :
- edsair.doi.dedup.....2b01ab590bca945d2ed606bbfc258ef5