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HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy
- Source :
- The Journal of allergy and clinical immunology. 144(5)
- Publication Year :
- 2018
-
Abstract
- Background Food allergy is a growing health problem worldwide because of its increasing prevalence, life-threatening potential, and shortage of effective preventive treatments. In an outbreak of wheat allergy in Japan, thousands of patients had allergic reactions to wheat after using soap containing hydrolyzed wheat protein (HWP). Objectives The aim of the present study was to investigate genetic variation that can contribute to susceptibility to HWP allergy. Methods We conducted a genome-wide association study of HWP allergy in 452 cases and 2700 control subjects using 6.6 million genotyped or imputed single nucleotide polymorphisms. Replication was assessed by genotyping single nucleotide polymorphisms in independent samples comprising 45 patients with HWP allergy and 326 control subjects. Results Through the genome-wide association study, we identified significant associations with the class II HLA region on 6p21 (P = 2.16 × 10−24 for rs9271588 and P = 2.96 × 10−24 for HLA-DQα1 amino acid position 34) and with the RBFOX1 locus at 16p13 (rs74575857, P = 8.4 × 10−9). The associations were also confirmed in the replication data set. Both amino acid polymorphisms (HLA-DQβ1 amino acid positions 13 and 26) located in the P4 binding pockets on the HLA-DQ molecule achieved the genome-wide significance level (P Conclusions Our data provide the first demonstration of genetic risk for HWP allergy and show that this genetic risk is mainly represented by multiple combinations of HLA variants.
- Subjects :
- 0301 basic medicine
Male
Allergy
Genotype
Immunology
Single-nucleotide polymorphism
Human leukocyte antigen
Wheat Hypersensitivity
Biology
Polymorphism, Single Nucleotide
Disease Outbreaks
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Japan
Food allergy
HLA-DQ Antigens
Genetic variation
HLA-DQ
medicine
Immunology and Allergy
Humans
Genetic Predisposition to Disease
Genotyping
Triticum
Genetics
Hydrolysis
Allergens
Antigens, Plant
Middle Aged
medicine.disease
030104 developmental biology
030228 respiratory system
Female
RNA Splicing Factors
Wheat allergy
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 10976825
- Volume :
- 144
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Journal of allergy and clinical immunology
- Accession number :
- edsair.doi.dedup.....2af285b2634f4735cd1db42010d48201