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Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation
- Source :
- Nutrition, Metabolism and Cardiovascular Diseases. 26:786-796
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background and aims Moderately reduced maternal nutrient availability during pregnancy has adverse effects on the fetuses' growth and metabolism during and after pregnancy. The aim of this study was to explore effects of maternal nutrition restriction (MNR) on key metabolites of the fetal energy metabolism, particularly amino acids (AA), nonesterified fatty acids (NEFA), acylcarnitines and phospholipids. These effects may reflect mechanisms relating MNR to later adverse outcomes. Methods and results Plasma and liver samples of fetal baboons, whose mothers were fed ad libitum (CTR) or MNR (70% of CTR), were collected at 0.5 and 0.9 gestation (G – term 184 days). Metabolites were measured with liquid chromatography coupled to mass spectrometry. In both, CTR and MNR, fetal metabolic profiles changed markedly between 0.5G and 0.9G. Fetal liver glucose concentrations were strongly increased. Hepatic levels of NEFA, sphingomyelins, and alkyl-linked phospholipids increased while plasma NEFA and acyl-linked phospholipids levels decreased with progression of gestation. At 0.5G, MNR fetal plasma levels of short- and medium-chain acylcarnitines were elevated, but did no longer differ between groups at 0.9G. At 0.9G, plasma levels of methionine and threonine as well as hepatic threonine levels were lower in the MNR group. Conclusion Small differences in the concentrations of plasma and liver metabolites between MNR and CTR fetuses reflect good adaptation to MNR. Fetal liver metabolic profiles changed markedly between the two gestation stages, reflecting enhanced liver glucose and lipid levels with advancing gestation. Decreased concentrations of AA suggest an up-regulation of gluconeogenesis in MNR.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Gestational Age
030209 endocrinology & metabolism
Fatty Acids, Nonesterified
Mass Spectrometry
03 medical and health sciences
chemistry.chemical_compound
Fetus
0302 clinical medicine
NEFA
Pregnancy
Carnitine
Internal medicine
medicine
Animals
Humans
Metabolomics
Phospholipids
Caloric Restriction
chemistry.chemical_classification
Nutrition and Dietetics
Chemistry
Malnutrition
Gluconeogenesis
Fatty acid
Maternal Nutritional Physiological Phenomena
Metabolism
Adaptation, Physiological
Disease Models, Animal
030104 developmental biology
Endocrinology
Liver
Metabolome
Gestation
Female
Cardiology and Cardiovascular Medicine
Biomarkers
PCAA
Chromatography, Liquid
Papio
medicine.drug
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....2ae22670653eb9c6ebe2bf850f919594
- Full Text :
- https://doi.org/10.1016/j.numecd.2016.04.004