Additional file 1 of Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging

Additional file 1: Results. Figure S1. Mitochondrial DNA content during the LostArc procedure. Figure S2. Internal controls for validation of the LostArc method. Figure S3. The COX-ve count is poorly explained by deletions in Complex IV genes alone. Figure S4. LostArc Report example #1: weighted mean of three HEK samples. Figure S5. LostArc Report example #2: young Gwt sample M01. Figure S6. Example fits to alternative replication/deletion models. Table S1. Sample list and deletion mapping statistics. Table S2. Patient symptoms and references associated with POLG variant samples [99–104].