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High‐Specificity In Vivo Tumor Imaging Using Bioorthogonal NIR‐IIb Nanoparticles
- Source :
- Advanced Materials. 33:2102950
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Lanthanide-based NIR-IIb nanoprobes are ideal for in vivo imaging. However, existing NIR-IIb nanoprobes often suffer from low tumor-targeting specificity, limiting their widespread use. Here the application of bioorthogonal nanoprobes with high tumor-targeting specificity for in vivo NIR-IIb luminescence imaging and magnetic resonance imaging (MRI) is reported. These dual-modality nanoprobes can enhance NIR-IIb emission by 20-fold and MRI signal by twofold, compared with non-bioorthogonal nanoprobes in murine subcutaneous tumors. Moreover, these bioorthogonal probes enable orthotopic brain tumor imaging. Implementation of bio-orthogonal chemistry significantly reduces the nanoprobe dose and hence cytotoxicity, providing a paradigm for real-time in vivo visualization of tumors.
- Subjects :
- Tumor imaging
Materials science
medicine.diagnostic_test
Brain Neoplasms
Mechanical Engineering
Optical Imaging
Brain tumor
Nanoparticle
Nanoprobe
Magnetic resonance imaging
equipment and supplies
medicine.disease
Lanthanoid Series Elements
Magnetic Resonance Imaging
Mice
Mechanics of Materials
In vivo
medicine
Animals
Nanoparticles
General Materials Science
Bioorthogonal chemistry
Preclinical imaging
Biomedical engineering
Subjects
Details
- ISSN :
- 15214095 and 09359648
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Advanced Materials
- Accession number :
- edsair.doi.dedup.....2ad82852acf296954d80e8dea8e00f91