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Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study
Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study
- Source :
- BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021), BMJ Open Diabetes Research & Care, 9(1):001698. BMJ Publishing Group, BMJ Open Diabetes Research & Care
- Publication Year :
- 2021
- Publisher :
- BMJ Publishing Group, 2021.
-
Abstract
- IntroductionDistal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methodsThis cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.ResultsAfter adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.ConclusionsThe associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN.
- Subjects :
- SCHWANN-CELLS
DIABETIC PERIPHERAL NEUROPATHY
diagnosis
Endocrinology, Diabetes and Metabolism
T cell
Neural Conduction
030209 endocrinology & metabolism
PROGRESSION
Adaptive Immunity
CD8-Positive T-Lymphocytes
T-CELL
Nerve conduction velocity
Diseases of the endocrine glands. Clinical endocrinology
ANTIGENS
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
cohort studies
subclinical inflammation
medicine
Humans
Pathophysiology/Complications
030304 developmental biology
0303 health sciences
business.industry
neurology
CYTOKINES
Acquired immune system
medicine.disease
RC648-665
Cross-Sectional Studies
medicine.anatomical_structure
Diabetes Mellitus, Type 2
type 2
CORNEAL CONFOCAL MICROSCOPY
inflammation
Immunology
diabetes mellitus
POLYNEUROPATHY
business
Polyneuropathy
CD8
Sensory nerve
Subjects
Details
- Language :
- English
- ISSN :
- 20524897
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMJ Open Diabetes Research & Care
- Accession number :
- edsair.doi.dedup.....2ad31dce26a33707b39bc4819f2357e3
- Full Text :
- https://doi.org/10.1136/bmjdrc-2020-001698