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Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study

Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study

Authors :
Jos P. H. Reulen
Dan Ziegler
Haifa Maalmi
Werner H. Mess
Coen D.A. Stehouwer
Casper G. Schalkwijk
Hans H.C.M. Savelberg
Nicolaas C. Schaper
Christian Herder
Jeroen H. P. M. van der Velde
Kristiaan Wouters
Michael Roden
Interne Geneeskunde
RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome
Nutrition and Movement Sciences
RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health
Klinische Neurowetenschappen
MUMC+: HZC Klinische Neurofysiologie (5)
MUMC+: HZC Med Staf Spec Klinische Neurofys (9)
RS: Carim - B06 Imaging
MUMC+: MA Med Staf Artsass Interne Geneeskunde (9)
MUMC+: MA Reumatologie (9)
MUMC+: MA Nefrologie (9)
MUMC+: MA Medische Oncologie (9)
MUMC+: MA Hematologie (9)
MUMC+: MA Maag Darm Lever (9)
MUMC+: MA Endocrinologie (9)
MUMC+: MA Interne Geneeskunde (3)
RS: Carim - V02 Hypertension and target organ damage
Source :
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021), BMJ Open Diabetes Research & Care, 9(1):001698. BMJ Publishing Group, BMJ Open Diabetes Research & Care
Publication Year :
2021
Publisher :
BMJ Publishing Group, 2021.

Abstract

IntroductionDistal sensorimotor polyneuropathy (DSPN) is common in people with diabetes but is also found in pre-diabetes. Peripheral nerve myelin damage, which can be assessed by reduced nerve conduction velocity (NCV), is an essential feature of DSPN. Emerging evidence indicates that the development of DSPN may involve the activation of the immune system. However, available studies have mainly investigated circulating immune mediators, whereas the role of immune cells remains unclear. Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methodsThis cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. NCV was measured in the peroneal and tibial motor nerves and the sural sensory nerve and summed to calculate a standardized NCV sum score. Associations between percentages of leukocyte subsets and NCV sum scores were estimated using linear regression models adjusted for demographic, lifestyle, metabolic and clinical covariates.ResultsAfter adjustment for covariates, higher percentages of basophils and CD4+ T cells were associated with lower NCV (p=0.014 and p=0.005, respectively). The percentage of CD8+ T cells was positively associated with NCV (p=0.022). These associations were not modified by glucose metabolism status (all pinteraction >0.05). No associations were found for monocytes, eosinophils, neutrophils, lymphocytes, total T cells, Treg cells and B cells.ConclusionsThe associations of basophils, CD4+ and CD8+ T cells with NCV suggest that cell types from both innate and adaptive immunity may be implicated in the development of DSPN.

Details

Language :
English
ISSN :
20524897
Volume :
9
Issue :
1
Database :
OpenAIRE
Journal :
BMJ Open Diabetes Research & Care
Accession number :
edsair.doi.dedup.....2ad31dce26a33707b39bc4819f2357e3
Full Text :
https://doi.org/10.1136/bmjdrc-2020-001698