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Monoaminergic Modulation of Spinal Viscero-Sympathetic Function in the Neonatal Mouse Thoracic Spinal Cord
- Source :
- PLoS ONE, Vol 7, Iss 11, p e47213 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Descending serotonergic, noradrenergic, and dopaminergic systems project diffusely to sensory, motor and autonomic spinal cord regions. Using neonatal mice, this study examined monoaminergic modulation of visceral sensory input and sympathetic preganglionic output. Whole-cell recordings from sympathetic preganglionic neurons (SPNs) in spinal cord slice demonstrated that serotonin, noradrenaline, and dopamine modulated SPN excitability. Serotonin depolarized all, while noradrenaline and dopamine depolarized most SPNs. Serotonin and noradrenaline also increased SPN current-evoked firing frequency, while both increases and decreases were seen with dopamine. In an in vitro thoracolumbar spinal cord/sympathetic chain preparation, stimulation of splanchnic nerve visceral afferents evoked reflexes and subthreshold population synaptic potentials in thoracic ventral roots that were dose-dependently depressed by the monoamines. Visceral afferent stimulation also evoked bicuculline-sensitive dorsal root potentials thought to reflect presynaptic inhibition via primary afferent depolarization. These dorsal root potentials were likewise dose-dependently depressed by the monoamines. Concomitant monoaminergic depression of population afferent synaptic transmission recorded as dorsal horn field potentials was also seen. Collectively, serotonin, norepinephrine and dopamine were shown to exert broad and comparable modulatory regulation of viscero-sympathetic function. The general facilitation of SPN efferent excitability with simultaneous depression of visceral afferent-evoked motor output suggests that descending monoaminergic systems reconfigure spinal cord autonomic function away from visceral sensory influence. Coincident monoaminergic reductions in dorsal horn responses support a multifaceted modulatory shift in the encoding of spinal visceral afferent activity. Similar monoamine-induced changes have been observed for somatic sensorimotor function, suggesting an integrative modulatory response on spinal autonomic and somatic function.
- Subjects :
- Sympathetic nervous system
Anatomy and Physiology
Sympathetic Nervous System
Dopamine
Visceral Afferents
Sensory Physiology
lcsh:Medicine
Mice
Norepinephrine
0302 clinical medicine
Ganglia, Spinal
Monoaminergic
lcsh:Science
Evoked Potentials
0303 health sciences
Ganglia, Sympathetic
Multidisciplinary
Dopaminergic
Anatomy
Sensory Systems
Electrophysiology
medicine.anatomical_structure
Spinal Cord
Neurology
Medicine
Spinal Nerve Roots
Research Article
medicine.drug
Serotonin
Calcitonin Gene-Related Peptide
Neurophysiology
Biology
Autonomic Nervous System
Serotonergic
Splanchnic nerves
Neurological System
03 medical and health sciences
Neurons, Efferent
medicine
Animals
030304 developmental biology
lcsh:R
Splanchnic Nerves
Spinal cord
lcsh:Q
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....2ab87c95b206091167b862b32571a609