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Helicobacter suis infection is associated with nodular gastritis‐like appearance of gastric mucosa‐associated lymphoid tissue lymphoma
- Source :
- Cancer Medicine, Cancer Medicine, Vol 8, Iss 9, Pp 4370-4379 (2019)
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- Most patients with gastric mucosa‐associated lymphoid tissue (MALT) lymphoma are infected with Helicobacter pylori, and eradication therapy is the first‐line treatment for localized disease with H pylori infection. However, there were several reports showing effectiveness of eradication therapy in even H pylori negative cases. Gastric MALT lymphomas are endoscopically classified into three common types: superficial, ulcerative, and elevated types. For the past 20 years, we have encountered 200 cases of localized gastric MALT lymphoma. Among them, only 4 cases (2%) showed similar macroscopic findings to those of nodular gastritis (gastric MALT lymphoma with nodular gastritis‐like appearance; M‐NGA). Here, we compared clinicopathological characteristics and prevalence of non‐H pylori Helicobacter (NHPH) infection between M‐NGA and other common types of gastric MALT lymphoma. To examine the prevalence of NHPH infection, DNA was extracted from formalin‐fixed paraffin‐embedded biopsy tissues from four cases of M‐NGA, 20 cases of common endoscopic types of gastric MALT lymphoma, and 10 cases of nodular gastritis. We used a highly sensitive polymerase chain reaction assay to detect the presence of five species of NHPH (Helicobacter suis, H felis, H bizzozeronii, H salomonis, and H heilmannii). H suis infection was detected in 4, 2, and 0 of the 4, 20, and 10 cases of M‐NGA, other types of gastric MALT lymphoma, and nodular gastritis, respectively. Other NHPH species were not detected in any cases. Complete response rate by eradication therapy was 4/4 in M‐NGA cases. Therefore, nodular gastritis‐like MALT lymphoma, which shows a very rare phenotype, is closely associated with NHPH infection, and eradication therapy may be the first‐choice treatment.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
non‐H pylori Helicobacter (NHPH)
Helicobacter heilmannii
Gastroenterology
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
Prevalence
Helicobacter
Original Research
Cancer Biology
medicine.diagnostic_test
biology
MALT lymphoma
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Lymphatic system
medicine.anatomical_structure
Treatment Outcome
Oncology
Helicobacter suis
030220 oncology & carcinogenesis
Gastritis
Drug Therapy, Combination
Adult
DNA, Bacterial
medicine.medical_specialty
lcsh:RC254-282
Helicobacter Infections
03 medical and health sciences
Internal medicine
Clarithromycin
Biopsy
medicine
Gastric mucosa
Humans
Radiology, Nuclear Medicine and imaging
Lansoprazole
nodular gastritis
mucosa‐associated lymphoid tissue
business.industry
Amoxicillin
Lymphoma, B-Cell, Marginal Zone
Helicobacter pylori
medicine.disease
biology.organism_classification
digestive system diseases
Lymphoma
030104 developmental biology
eradication therapy
business
Mucosa-associated lymphoid tissue
Subjects
Details
- Language :
- English
- ISSN :
- 20457634
- Volume :
- 8
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....2ab4d61bc630cdd443116391785cf959