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Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: Randomized, double-blind, placebo-controlled trial
- Source :
- Nutrition. 31:1235-1242
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Objective To our knowledge, no reports are available indicating the effects of selenium supplementation on metabolic parameters, inflammatory factors, and oxidative stress in gestational diabetes mellitus (GDM). The aim of this study was to assess the effects of selenium supplementation on metabolic status in pregnant women with GDM who were not on oral hypoglycemic agents. Methods This randomized, double-blind, placebo-controlled clinical trial was performed with 70 women with GDM. Patients were randomly assigned to receive either 200 μg selenium supplements as tablet (n = 35) or placebo (n = 35) for 6 wk from weeks 24 to 28 of gestation. Fasting plasma samples were taken at study baseline and after 6 wk of intervention to quantify related variables. Results Selenium supplementation, compared with placebo, resulted in a significant reduction in fasting plasma glucose (−10.5 ± 11.9 versus +4.5 ± 12.9 mg/dL; P
- Subjects :
- Adult
Blood Glucose
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Placebo-controlled study
chemistry.chemical_element
Placebo
Antioxidants
Selenium
Insulin resistance
Double-Blind Method
Pregnancy
Internal medicine
medicine
Homeostasis
Humans
Glucose homeostasis
Nutrition and Dietetics
biology
business.industry
Quantitative insulin sensitivity check index
C-reactive protein
Fasting
medicine.disease
Glutathione
Gestational diabetes
Diabetes, Gestational
Oxidative Stress
C-Reactive Protein
Endocrinology
chemistry
Dietary Supplements
biology.protein
Female
Insulin Resistance
business
Subjects
Details
- ISSN :
- 08999007
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Nutrition
- Accession number :
- edsair.doi.dedup.....2aaf5d04d213bb35e2be31f5718707b4