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Non-invasive assessment of liver fibrosis in patients with HBV-related chronic liver disease undergoing antiviral treatment: A preliminary study
- Source :
- European journal of pharmacology. 806
- Publication Year :
- 2016
-
Abstract
- In chronic hepatitis B (CHB) patients, fibrosis assessment during antiviral treatment is a key step in the clinical management. Aim of this study was to evaluate the performance of elastography in assessing fibrosis stage in CHB before and after two years of nucleoside/nucleotide analogues (NUC) treatment in comparison with indirect serum markers. CHB diagnosis was made according to standard criteria. A clinical and virological evaluation was performed at baseline and again at 3, 6, 9, 12 18, and 24 months during treatment. Fibrosis was evaluated by liver biopsy, elastography and indirect serum markers. Of 75 patients, 50 had CHB, HBeAg negative and were deemed eligible for this study. Of these, 22 underwent liver biopsy. Mean histo-morphometric values of fibrotic tissue differed significantly in the stage < S3 vs. stage ≥S3: 2.01±2.62% vs. 12.85±7.31% (p=0.03), respectively. At 18 and 24 months, stiffness values were statistically reduced from those previously observed (P=0.03 and P
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Liver fibrosis
Chronic liver disease
Gastroenterology
Antiviral Agents
03 medical and health sciences
0302 clinical medicine
Hepatitis B, Chronic
Fibrosis
Internal medicine
medicine
Humans
Stage (cooking)
Pharmacology
Hepatitis
medicine.diagnostic_test
business.industry
Entecavir
Middle Aged
medicine.disease
Surgery
030220 oncology & carcinogenesis
Liver biopsy
Elasticity Imaging Techniques
030211 gastroenterology & hepatology
Female
Elastography
business
HBV
Liver stiffness
Nucleos(t)ide analogues
Tenofovir
medicine.drug
Subjects
Details
- ISSN :
- 18790712
- Volume :
- 806
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....2aa01913478f2aeffc9bbf40c119d916