Reference Ranges in [(99m)Tc]Mercaptoacetyltriglycerine Renography:Comparison of a Semi-automated (Xeleris, GE) and Manual (Picker, Odyssey) Processing Software

PURPOSE: The purpose of the study was to define reference ranges for quantitative parameters in [(99m)Tc]mercaptoacetyltriglycerine ([(99m)Tc]MAG3) renography to assist interpretation in a semi-automated (Xeleris, GE) compared to a manual (Picker, Odyssey) software package.PROCEDURES: Forty-eight subjects approved for renal donation were evaluated with [(99m)Tc]MAG3 renography using both the Xeleris and the Picker software.RESULTS: Reference ranges for the two software were comparable regarding the relative function of the two kidneys (the split function, SF) and the residual activities (RA). The time to peak whole-kidney activities (T max whole-kidney) was more dependent on the type of software. Using Bland-Altman limits, we found good and acceptable agreement between the two methods.CONCLUSIONS: We found good correlation between renography results using the Xeleris and Picker software packages. However, software-specific reference ranges are needed.