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Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 4, p e0176138 (2017)
- Publication Year :
- 2017
- Publisher :
- Columbia University, 2017.
-
Abstract
- Introduction Short telomere length has been suggested to be associated with atherosclerotic changes in Western populations. We examined the relationships between leukocyte telomere length and cardiovascular and renal function in a Japanese cohort. Participants and methods We enrolled 770 subjects who each had at least one cardiovascular risk factor. The mean age was 59.5 ± 12.2 years; mean BMI was 25.1 ± 4.6 kg/m2. We measured leukocyte telomere length (LTL) by quantitative PCR (T/S ratio), and measured other biomarkers from blood and urine samples. In addition, we assessed surrogate markers of arterial stiffness, cardiovascular organ damage and kidney function, including flow-mediated vasodilation (FMD), pulse wave velocity (PWV), carotid artery augmentation index (CAAI), and urinary albumin creatinine ratio (UACR) and eGFR. Results Leukocyte telomere length (T/S ratio) was inversely associated with age (r = -0.194, P
- Subjects :
- Male
lcsh:Medicine
Blood Pressure
Urine
030204 cardiovascular system & hematology
Kidney
Biochemistry
Vascular Medicine
Stiffness
White Blood Cells
chemistry.chemical_compound
Endocrinology
0302 clinical medicine
Japan
Animal Cells
Risk Factors
Medicine and Health Sciences
Medicine
lcsh:Science
Pulse wave velocity
Telomere Length
Multidisciplinary
Chromosome Biology
Middle Aged
Telomere
Telomeres
Cardiovascular Diseases
Creatinine
Hypertension
Physical Sciences
Cohort
Cardiology
Female
Cellular Types
Anatomy
Research Article
Chromosome Structure and Function
medicine.medical_specialty
Endocrine Disorders
Immune Cells
Immunology
Materials Science
Material Properties
Renal function
Pulse Wave Analysis
Chromosomes
03 medical and health sciences
Vascular Stiffness
Kidneys--Diseases
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Mechanical Properties
Humans
Risk factor
Aged
Japanese--Health and hygiene
Blood Cells
business.industry
lcsh:R
Biology and Life Sciences
Cell Biology
Renal System
medicine.disease
chemistry
Metabolic Disorders
Arterial stiffness
lcsh:Q
business
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, Vol 12, Iss 4, p e0176138 (2017)
- Accession number :
- edsair.doi.dedup.....2a87b063d2894458fe5ab8b2e8f3541d
- Full Text :
- https://doi.org/10.7916/d8vh6130