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MRI-based kidney radiomic analysis during chronic lithium treatment
- Source :
- European Journal of Clinical Investigation, European Journal of Clinical Investigation, 2022, 52 (5), pp.e13756. ⟨10.1111/eci.13756⟩
- Publication Year :
- 2022
-
Abstract
- International audience; Background: Lithium therapy during bipolar disorder is associated with an increased risk of chronic kidney disease (CKD) that is slowly progressive and undetectable at early stages. We aimed at identifying kidney image texture features as possible imaging biomarkers of decreased measured glomerular filtration rate (mGFR) using radiomics of T2-weighted magnetic resonance imaging (MRI).Methods: One hundred and eight patients treated with lithium were evaluated including mGFR and kidney MRI, with T2-weighted sequence single-shot fast spin-echo. Computed radiomic analysis was performed after kidney segmentation. Significant features were selected to build a radiomic signature using multivariable Cox analysis to detect an mGFR
- Subjects :
- bipolar disorder
MESH: Humans
MESH: Lithium
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
MESH: Renal Insufficiency, Chronic
Clinical Biochemistry
MESH: Kidney
General Medicine
MESH: Lithium Compounds
Lithium
Kidney
Biochemistry
Magnetic Resonance Imaging
MESH: Magnetic Resonance Imaging
MESH: Glomerular Filtration Rate
radiomics
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Lithium Compounds
Humans
Renal Insufficiency, Chronic
chronic kidney disease
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 13652362 and 00142972
- Volume :
- 52
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of clinical investigationREFERENCES
- Accession number :
- edsair.doi.dedup.....2a7cdf7056e36f18e53c3f81e49f34d9