Cerebrospinal fluid manganese concentrations in patients with symmetric pallidal hyperintensities on T1 weighted MRI

Recently, there have been some reports that MRI shows characteristic brain lesions in patients with parenteral nutrition containing manganese (Mn), or hepatic failure, and that the serum or whole blood Mn concentration is often increased.1-3 T1 weighted MRI in these patients has shown hyperintensity, always in the bilateral globus pallidus and sometimes in part of the brainstem, although no abnormalities have been found on T2 weighted MRI. The Mn concentrations of CSF in these patients, however, have not been previously measured, because values in control subjects were previously undetermined. The present study was designed to investigate the CSF Mn concentrations in control subjects, and to evaluate the concentrations in patients with symmetric pallidal hyperintensities on T1 weighted MRI. View this table: Serum, whole blood, and CSF Mn concentrations in five patients with hyperintensity on T1 weighted MRI and 10 control subjects without hyperintensity We examined five patients with the appropriate hyperintensity on T1 weighted MRI, aged from 31 to 72 years (mean 55.8 (SD 16.9) years); two with parenteral nutrition containing …