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Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation
- Source :
- Immunological reviews. 272(1)
- Publication Year :
- 2016
-
Abstract
- Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.
- Subjects :
- 0301 basic medicine
Immunological Synapses
T-Lymphocytes
Immunology
Antigen presentation
CD1
Biology
Lymphocyte Activation
03 medical and health sciences
0302 clinical medicine
Antigen
Cell Movement
Histocompatibility Antigens
MHC class I
Immunology and Allergy
Animals
Humans
Antigens
Antigen-presenting cell
Cytoskeleton
MHC class II
Antigen Presentation
B-Lymphocytes
Antigen processing
Cell Membrane
Dendritic Cells
MHC restriction
Endocytosis
Cell biology
030104 developmental biology
biology.protein
Peptides
030215 immunology
Subjects
Details
- ISSN :
- 1600065X
- Volume :
- 272
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Immunological reviews
- Accession number :
- edsair.doi.dedup.....2a73af5561117df2ad7a80e5088c756a