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Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation

Authors :
Paolo Pierobon
Anita Kumari
Dorian Obino
Ana-Maria Lennon-Duménil
Violaine Randrian
Pablo J. Sáez
Odile Malbec
Hélène D. Moreau
Marine Bretou
Source :
Immunological reviews. 272(1)
Publication Year :
2016

Abstract

Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.

Details

ISSN :
1600065X
Volume :
272
Issue :
1
Database :
OpenAIRE
Journal :
Immunological reviews
Accession number :
edsair.doi.dedup.....2a73af5561117df2ad7a80e5088c756a