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Human T-Cell Leukemia Virus Type 1 Infection Is a Risk Factor for Atherosclerosis
- Source :
- Journal of Clinical Medicine Research
- Publication Year :
- 2021
- Publisher :
- Elmer Press, 2021.
-
Abstract
- Background: Infection, such as by human immunodeficiency virus (HIV), has been reported to cause atherosclerosis by inducing inflammation. Because human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus, as is HIV, we investigated the possible influence of HTLV-1 on the pathogenesis of atherosclerosis by use of established atherosclerosis parameters. Methods: The study was done on Iki Island, Fukuoka, an area endemic for HTLV-1. The data of 1,424 residents who reported to an annual health check were available for analysis. Anti-HTLV-1 antibody status and factors associated with atherosclerosis were examined, including maximum intima-media thickness (Max-IMT) and brachial-ankle pulse wave velocity (PWV). Results: HTLV-1 positive participants had significantly higher Max-IMT (1.15 ± 0.55 vs. 1.08 ± 0.61 mm, P = 0.04) and PWV (1,760.6 ± 414.5 vs. 1,657.1 ± 425.5 cm/s, P < 0.01) values than did those negative. Moreover, in multiple regression analysis (odds ratio: 1.39, P < 0.01) of participants with Max-IMT 1.1 mm or over, HTLV-1 was extracted as an independent factor for the development of atherosclerosis. Conclusion: Our results indicate that HTLV-1 infection confers a high risk of atherosclerosis, although its opposite relation is also possible. It is important to carefully follow the health status of HTLV-1 carriers. J Clin Med Res. 2021;13(3):164-169 doi: https://doi.org/10.14740/jocmr4457
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Inflammation
Gastroenterology
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Retrovirus
Internal medicine
medicine
030212 general & internal medicine
Risk factor
Pulse wave velocity
biology
IMT
business.industry
General Medicine
Odds ratio
medicine.disease
biology.organism_classification
Atherosclerosis
Leukemia
030104 developmental biology
HTLV-1
biology.protein
Original Article
Antibody
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 19183011 and 19183003
- Volume :
- 13
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine Research
- Accession number :
- edsair.doi.dedup.....2a642d21eefbe49c27fc99ce9343bf59