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Transluminal attenuation gradient derived from coronary CT angiography to predict ischemia in SPECT myocardial perfusion imaging: Effect of coronary cross-sectional area
- Publication Year :
- 2022
- Publisher :
- Springer, 2022.
-
Abstract
- BACKGROUND Coronary computed tomography angiography (CCTA)-based transluminal attenuation gradient (TAG) was suggested to determine the functional significance of a stenosis. However, evidence that TAG acquired by wide-volume scanners can assess the hemodynamic significance of stenosis assessed by single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is lacking. Moreover, coronary cross-sectional area may influence TAG. Hence, we aimed at assessing the diagnostic value of TAG to predict ischemia in SPECT-MPI and the correlation between TAG and the transluminal cross-sectional area gradient (TCG). METHODS Patients undergoing CCTA and SPECT-MPI for suspected coronary artery disease were included. TAG and TCG were calculated measuring the mean vessel attenuation and the cross-sectional area along major coronary vessels at 5-mm intervals. RESULTS A total of 255 coronary arteries of 87 patients were included. TAG and TCG did not discriminate between coronary arteries with or without ischemia as assessed by SPECT-MPI (p = .44 and p = .25, respectively). The area under the curve to predict ischemia was not increased by adding TAG (0.88, 95% CI 0.83-0.92) or TCG (0.87, 95% CI 0.81-0.90) to CCTA alone (0.85, 95% CI 0.80-0.89). There was a significant correlation between TAG and TCG (r = 0.43; p
- Subjects :
- medicine.medical_specialty
Ischemia
610 Medicine & health
030204 cardiovascular system & hematology
Single-photon emission computed tomography
2705 Cardiology and Cardiovascular Medicine
030218 nuclear medicine & medical imaging
Coronary artery disease
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Internal medicine
medicine
2741 Radiology, Nuclear Medicine and Imaging
Radiology, Nuclear Medicine and imaging
Computed tomography angiography
medicine.diagnostic_test
business.industry
10181 Clinic for Nuclear Medicine
medicine.disease
Coronary arteries
Stenosis
medicine.anatomical_structure
10209 Clinic for Cardiology
Cardiology
Cardiology and Cardiovascular Medicine
business
Emission computed tomography
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....2a608d2bd27cd55110bae7bb4a9723cc
- Full Text :
- https://doi.org/10.5167/uzh-189295