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Delivery of drugs into brain tumors using multicomponent silica nanoparticles

Authors :
Gil Covarrubias
Ramamurthy Gopalakrishnan
S. Raghunathan
Pubudu M. Peiris
Abdelrahman Rahmy
Kathleen Tong
Mark A. Griswold
Morgan E Lorkowski
T Ouyang
A Yun
Efstathios Karathanasis
Vindya S. Perera
Peter Bielecki
Ketan B. Ghaghada
Oguz Turan
Source :
Nanoscale
Publication Year :
2019

Abstract

Glioblastomas are highly lethal cancers defined by resistance to conventional therapies and rapid recurrence. While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting factor. We developed a multicomponent nanoparticle, consisting of an iron oxide core and a mesoporous silica shell that can effectively deliver drugs across the blood-brain barrier into glioma cells. When exposed to alternating low-power radiofrequency (RF) fields, the nanoparticle's mechanical tumbling releases the entrapped drug molecules from the pores of the silica shell. After directing the nanoparticle to target the near-perivascular regions and altered endothelium of the brain tumor via fibronectin-targeting ligands, rapid drug release from the nanoparticles is triggered by RF facilitating wide distribution of drug delivery across the blood-brain tumor interface.

Details

Language :
English
Database :
OpenAIRE
Journal :
Nanoscale
Accession number :
edsair.doi.dedup.....2a37b73b948b75fa950e969742ddf55f