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Delivery of drugs into brain tumors using multicomponent silica nanoparticles
- Source :
- Nanoscale
- Publication Year :
- 2019
-
Abstract
- Glioblastomas are highly lethal cancers defined by resistance to conventional therapies and rapid recurrence. While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting factor. We developed a multicomponent nanoparticle, consisting of an iron oxide core and a mesoporous silica shell that can effectively deliver drugs across the blood-brain barrier into glioma cells. When exposed to alternating low-power radiofrequency (RF) fields, the nanoparticle's mechanical tumbling releases the entrapped drug molecules from the pores of the silica shell. After directing the nanoparticle to target the near-perivascular regions and altered endothelium of the brain tumor via fibronectin-targeting ligands, rapid drug release from the nanoparticles is triggered by RF facilitating wide distribution of drug delivery across the blood-brain tumor interface.
- Subjects :
- Drug
media_common.quotation_subject
Brain tumor
Nanoparticle
Mice, Nude
02 engineering and technology
010402 general chemistry
Blood–brain barrier
01 natural sciences
Ferric Compounds
Article
Mice
Glioma
Cell Line, Tumor
medicine
Distribution (pharmacology)
Animals
General Materials Science
media_common
Drug Carriers
Chemistry
Brain Neoplasms
Mesoporous silica
021001 nanoscience & nanotechnology
medicine.disease
Silicon Dioxide
0104 chemical sciences
medicine.anatomical_structure
Blood-Brain Barrier
Drug delivery
Biophysics
Nanoparticles
Female
0210 nano-technology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....2a37b73b948b75fa950e969742ddf55f