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Survival outcomes and effect of early vs. deferred cART among HIV-infected patients diagnosed at the time of an AIDS-defining event: a cohort analysis
- Source :
- PLoS ONE, Vol 6, Iss 10, p e26009 (2011), PLoS ONE, Recercat. Dipósit de la Recerca de Catalunya, instname, Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2011
- Publisher :
- Public Library of Science (PLoS), 2011.
-
Abstract
- Objectives: We analyzed clinical progression among persons diagnosed with HIV at the time of an AIDS-defining event, and assessed the impact on outcome of timing of combined antiretroviral treatment (cART). Methods: Retrospective, European and Canadian multicohort study.. Patients were diagnosed with HIV from 1997-2004 and had clinical AIDS from 30 days before to 14 days after diagnosis. Clinical progression (new AIDS event, death) was described using Kaplan-Meier analysis stratifying by type of AIDS event. Factors associated with progression were identified with multivariable Cox regression. Progression rates were compared between those starting early (
- Subjects :
- Male
Time Factors
HAART
HIV opportunistic infections
lcsh:Medicine
HIV Infections
Cohort Studies
Interquartile range
Risk Factors
Antiretroviral Therapy, Highly Active
lcsh:Science
Multidisciplinary
Hazard ratio
Obstetrics and Gynecology
Antiretrovirals
HIV diagnosis and management
Middle Aged
Antivirals
Europe
AIDS
Anti-Retroviral Agents
HIV epidemiology
HIV
Disease Progression
Medicine
Infectious diseases
HIV clinical manifestations
Female
Viral load
Cohort study
Research Article
Adult
medicine.medical_specialty
Canada
Clinical Research Design
Urology
Sida
Retrovirology and HIV immunopathogenesis
Viral diseases
Therapeutics
Microbiology
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
Virology
medicine
VIH (Virus)
Humans
Biology
Survival analysis
Retrospective Studies
Acquired Immunodeficiency Syndrome
Proportional hazards model
business.industry
Genitourinary Infections
HIV (Viruses)
lcsh:R
Retrospective cohort study
medicine.disease
Terapèutica
Survival Analysis
Antiretroviral agents
Immunology
AIDS (Disease)
lcsh:Q
HIV-positive persons
business
Persones seropositives
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....2a23150cfdf457c086dc3aec12218df3