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Laboratory investigations in lipidology
- Source :
- SAMJ: South African Medical Journal, Volume: 108, Issue: 4, Pages: 266-270, Published: APR 2018, South African Medical Journal; Vol 108, No 4 (2018); 266-270, South African Medical Journal, Vol 108, Iss 4, Pp 266-270 (2018)
- Publication Year :
- 2018
- Publisher :
- Health and Medical Publishing Group, 2018.
-
Abstract
- Advances in the causes of disorders of lipid metabolism, and effective intervention in atherosclerosis with medication, have increased the reliance on laboratory investigation in clinical practice. The conventional lipid profile, comprising fasting triglyceride, total cholesterol, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol, suffices for screening persons at risk of atherosclerosis. Additionally, lipoprotein (a) measurement enhances risk assessment and could explain atherosclerosis with a desirable lipid profile. Certain rare disorders in sterol and fatty acid metabolism do not alter the conventional lipid profile. Non-fasting samples are gaining popularity, as the triglycerides, although mildly increased, signify atherogenic lipoprotein remnant accumulation. Apoprotein A1 (apo A1) and apo B concentrations parallel HDL cholesterol and LDL cholesterol, respectively, and are of value in disorders of these lipoproteins. In severe dyslipoproteinaemia, special investigations establish the cause of the disease and may allow selection of better treatment. In such cases, not only apoprotein concentrations, but also enzyme or cell function, as well as genetic investigations, are relevant. The most important genetic disorders to recognise are familial hypercholesterolaemia, dysbetalipoproteinaemia and chylomicronaemia. Expertise in lipidology is limited in South Africa, but specialist centres can provide clinical and laboratory support to ensure best management of severe disorders.
- Subjects :
- lcsh:R5-920
medicine.medical_specialty
medicine.diagnostic_test
Fatty acid metabolism
Triglyceride
Apolipoprotein B
biology
business.industry
Cholesterol
lcsh:R
lcsh:Medicine
Lipid metabolism
General Medicine
chemistry.chemical_compound
Endocrinology
chemistry
Internal medicine
biology.protein
Medicine
lipids (amino acids, peptides, and proteins)
lcsh:Medicine (General)
business
Lipid profile
Lipidology
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 20785135
- Database :
- OpenAIRE
- Journal :
- SAMJ: South African Medical Journal, Volume: 108, Issue: 4, Pages: 266-270, Published: APR 2018, South African Medical Journal; Vol 108, No 4 (2018); 266-270, South African Medical Journal, Vol 108, Iss 4, Pp 266-270 (2018)
- Accession number :
- edsair.doi.dedup.....2a1814fafdb542faa26df27bbfae6ccd