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Early Changes in Ghrelin following Roux-en-Y Gastric Bypass: Influence of Vagal Nerve Functionality?
- Source :
- Obesity Surgery. 17:304-310
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Roux-en-Y gastric bypass (RYGBP) effectively produces massive weight reduction, improving health in morbidly obese patients. The mechanisms for the weight loss, and the fate of the excluded gastric mucosa, are not fully clarified. To what extent the appetite-stimulating gastric peptide ghrelin is affected remains controversial. Circulating concentrations of ghrelin, pancreatic polypeptide (PP), pepsinogen I (PGI) and gastrin were examined in 15 morbidly obese patients (median BMI 45 kg/m2) preoperatively, and on days 1, 2, 4, 6 and at months 1, 6 and 12 after RYGBP. Ghrelin levels fell on postoperative day 1 and increased after 1 month to preoperative levels, and rose further at 6 and 12 months. PP concentrations decreased on day 1 and subsequently returned to preoperative levels. PGI levels peaked transiently the first days after surgery and subsequently declined to lower than preoperative levels. Gastrin levels were gradually reduced postoperatively. Ghrelin and PP fall transiently after surgery, possibly due to vagal dysfunction, and ultimately, as weight loss ensues, ghrelin secretion increases to higher than preoperative levels. The RYBGP procedure affects the gastric mucosa, as reflected by a transient increase in circulating PGI, and subsequently, the mucosa in the excluded stomach is at rest, as shown by low levels of PGI and gastrin.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Peptide Hormones
Endocrinology, Diabetes and Metabolism
Gastric Bypass
Radioimmunoassay
Pancreatic Polypeptide
Body Mass Index
Pepsin
Weight loss
Pepsinogen A
Internal medicine
Gastric Stump
Gastrins
Weight Loss
Gastric mucosa
medicine
Humans
Pancreatic polypeptide
Postoperative Period
Gastrin
Nutrition and Dietetics
biology
business.industry
Stomach
digestive, oral, and skin physiology
Vagus Nerve
Middle Aged
Ghrelin
medicine.anatomical_structure
Endocrinology
Gastric Mucosa
biology.protein
Female
Surgery
medicine.symptom
business
Ghrelin secretion
Subjects
Details
- ISSN :
- 17080428 and 09608923
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Obesity Surgery
- Accession number :
- edsair.doi.dedup.....2a11803f99054818148b51f6066ed914
- Full Text :
- https://doi.org/10.1007/s11695-007-9056-8