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HSV oropharyngeal shedding among HIV-infected children in Tanzania
- Source :
- International Journal of STD & AIDS. 26:456-461
- Publication Year :
- 2014
- Publisher :
- SAGE Publications, 2014.
-
Abstract
- Herpes simplex virus (HSV) oral shedding has not been studied among HIV-positive children in Africa. We sought to evaluate longitudinal oral HSV reactivation in HIV-positive and -negative children. Twenty HIV-positive antiretroviral-naive and 10 HIV-negative children aged 3–12 years in Tanzania were followed prospectively for 14 days. Oral swabs were collected daily and submitted for HSV DNA PCR analysis. Clinical data were collected via chart review and daily diaries. HSV DNA was detected in 10 (50%) of HIV-positive and 4 (40%) of HIV-negative children. Children who shed HSV had virus detected in a median of 21.4% of samples; shedding was intermittent. Median CD4 count among HIV-infected children was 667 cells/µL in those with positive HSV DNA and 886 cells/µL in those who were negative ( p = 0.6). Of the HIV-positive children reporting prior sores, five (83%) had positive HSV swabs, whereas the one HIV-negative child with prior sores did not have a PCR-positive swab. HSV is detected frequently in children with and without HIV. HIV-infected children reporting oral sores have a high rate of HSV detection. Given the proven strong interactions between HIV and HSV, further study of co-infection with these viruses is warranted in children.
- Subjects :
- Male
Herpesvirus 2, Human
viruses
Human immunodeficiency virus (HIV)
Oropharynx
Dermatology
HSL and HSV
Real-Time Polymerase Chain Reaction
medicine.disease_cause
Tanzania
Virus
Acquired immunodeficiency syndrome (AIDS)
HIV Seronegativity
Surveys and Questionnaires
Hiv infected
HIV Seropositivity
Humans
Medicine
Pharmacology (medical)
Prospective Studies
Viral shedding
Child
Herpes Genitalis
biology
Coinfection
business.industry
Public Health, Environmental and Occupational Health
virus diseases
medicine.disease
biology.organism_classification
Virology
CD4 Lymphocyte Count
Virus Shedding
Infectious Diseases
Herpes simplex virus
Case-Control Studies
Child, Preschool
DNA, Viral
HIV-1
Female
Virus Activation
business
Subjects
Details
- ISSN :
- 17581052 and 09564624
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- International Journal of STD & AIDS
- Accession number :
- edsair.doi.dedup.....2a0f4d1857e851e70eb842e8c1026935