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Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5 years of age
- Source :
- Thorax
- Publication Year :
- 2013
- Publisher :
- BMJ, 2013.
-
Abstract
- Background Newborn screening allows novel treatments for cystic fibrosis (CF) to be trialled in early childhood before irreversible lung injury occurs. As respiratory exacerbations are a potential trial outcome variable, we determined their rate, duration and clinical features in preschool children with CF; and whether they were associated with growth, lung structure and function at age 5 years. Methods Respiratory exacerbations were recorded prospectively in Australasian CF Bronchoalveolar Lavage trial subjects from enrolment after newborn screening to age 5 years, when all participants underwent clinical assessment, chest CT scans and spirometry. Results 168 children (88 boys) experienced 2080 exacerbations, at an average rate of 3.66 exacerbations per person-year; 80.1% were community managed and 19.9% required hospital admission. There was an average increase in exacerbation rate of 9% (95% CI 4% to 14%; p
- Subjects :
- Lung Diseases
Male
Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Cystic Fibrosis
Exacerbation
Respiratory Infection
Lung injury
Bronchoalveolar Lavage
03 medical and health sciences
0302 clinical medicine
Forced Expiratory Volume
030225 pediatrics
Internal medicine
medicine
Humans
Prospective Studies
Prospective cohort study
Lung
Bronchiectasis
medicine.diagnostic_test
business.industry
Incidence
Infant, Newborn
Infant
Respiratory infection
Antibiotic Prophylaxis
Prognosis
medicine.disease
Anti-Bacterial Agents
3. Good health
Hospitalization
Bronchoalveolar lavage
medicine.anatomical_structure
030228 respiratory system
Child, Preschool
Physical therapy
Female
Radiography, Thoracic
Tomography, X-Ray Computed
business
Follow-Up Studies
New Zealand
Subjects
Details
- ISSN :
- 14683296 and 00406376
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Thorax
- Accession number :
- edsair.doi.dedup.....2a010c516b56b4ab7b84646d51dd89a5