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Clinical and Radiologic Disease in Smokers With Normal Spirometry
- Source :
- JAMA internal medicine, vol 175, iss 9
- Publication Year :
- 2015
- Publisher :
- eScholarship, University of California, 2015.
-
Abstract
- ImportanceAirflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free.ObjectiveTo identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0.Design, setting, and participantsIndividuals from the Genetic Epidemiology of COPD (COPDGene) cross-sectional observational study completed spirometry, chest computed tomography (CT) scans, a 6-minute walk, and questionnaires. Participants were recruited from local communities at 21 sites across the United States. The GOLD 0 group (n = 4388) (ratio of forced expiratory volume in the first second of expiration [FEV1] to forced vital capacity >0.7 and FEV1 ≥80% predicted) from the COPDGene study was compared with a GOLD 1 group (n = 794), COPD groups (n = 3690), and a group of never smokers (n = 108). Recruitment began in January 2008 and ended in July 2011.Main outcomes and measuresPhysical function impairments, respiratory symptoms, CT abnormalities, use of respiratory medications, and reduced respiratory-specific quality of life.ResultsOne or more respiratory-related impairments were found in 54.1% (2375 of 4388) of the GOLD 0 group. The GOLD 0 group had worse quality of life (mean [SD] St George's Respiratory Questionnaire total score, 17.0 [18.0] vs 3.8 [6.8] for the never smokers; P
- Subjects :
- Male
Vital capacity
Thoracic
Pulmonary Disease, Chronic Obstructive
Tomography
Lung
COPD
education.field_of_study
Exercise Tolerance
medicine.diagnostic_test
Smoking
Middle Aged
Nutrition Surveys
Obstructive lung disease
X-Ray Computed
Respiratory
Public Health and Health Services
Bronchitis
Genetic Epidemiology of COPD (COPDGene) Investigators
Radiography, Thoracic
Female
medicine.symptom
Spirometry
medicine.medical_specialty
Chronic Obstructive
Chronic Obstructive Pulmonary Disease
Population
Clinical Sciences
Air trapping
Article
Pulmonary Disease
Clinical Research
Opthalmology and Optometry
Internal medicine
Tobacco
Internal Medicine
medicine
Humans
education
Asthma
Aged
Emphysema
Tobacco Smoke and Health
business.industry
medicine.disease
United States
respiratory tract diseases
Radiography
Cross-Sectional Studies
Case-Control Studies
Physical therapy
Quality of Life
Tomography, X-Ray Computed
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- JAMA internal medicine, vol 175, iss 9
- Accession number :
- edsair.doi.dedup.....29fed34ab7cba1f73bd610d0b6b6edb6