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Effect of Human Immunodeficiency Virus Type 1 on Intracellular Activation and Superoxide Production by Neutrophils
- Source :
- The Journal of Infectious Diseases. 180:206-210
- Publication Year :
- 1999
- Publisher :
- Oxford University Press (OUP), 1999.
-
Abstract
- Effect of Human Immunodeficiency Virus Type 1 on Intracellular Activation and Superoxide Production by Neutrophils (Muñoz, José F.; Salmen, Siham; Berrueta, Lisbeth R.; Cova, José A.; Donis, José H.; Hernández, Manuel R. and Torres, José V.) Abstract The immunopathogenesis of AIDS is associated with the development of opportunistic infections by intracellular pathogens that can invade and reproduce freely because of impaired cellular functions. Neutrophils from asymptomatic human immunodeficiency virus (HIV) type 1-infected persons and from symptomatic patients with AIDS were found to retain normal phagocytosis activity while producing significantly less superoxide than neutrophils fromHIV-1-negative subjects, when stimulated through Fc receptors or protein kinase C. After priming with a synthetic HIV-1 envelope peptide and stimulation via the Fc receptor, the neutrophils from HIV-1-negative controls had suppressed superoxide production, reduced phosphorylation of two unidentified cellular proteins, and increased expression of a third phosphoprotein. These results suggest that HIV-1 can produce direct functional damage of neutrophils through binding of envelope components to the cell membrane. Artículo publicado en: The Journal of Infectious Diseases 1999; 180:206-10. munozjose@hotmail.com donis@ula.ve sihamsa@ula.ve lberruet@ula.ve jvtorres@ucdavis.edu Nivel monográfico
- Subjects :
- Adult
Male
Adolescent
Phagocytosis
Fc receptor
HIV Infections
Receptors, Fc
Biology
Neutrophil Activation
Virus
Microbiology
chemistry.chemical_compound
Superoxides
Facultad de Medicina
Humans
Immunology and Allergy
Phosphorylation
Protein kinase A
Receptor
Protein Kinase C
Superoxide
Intracellular parasite
HIV- Sida
Gene Products, env
Artículos
Middle Aged
Phosphoproteins
Peptide Fragments
Infectious Diseases
chemistry
HIV-1
biology.protein
HIV/AIDS
Female
Inglés
Instituto de Inmunología Clínica (IDIC)
Intracellular
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....29f81dc32bd67f598346b91f064194ee