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Development of Neurological Disease Is Associated with Increased Immune Activation in Simian Immunodeficiency Virus-Infected Macaques
- Source :
- Journal of Virology. 86:13795-13799
- Publication Year :
- 2012
- Publisher :
- American Society for Microbiology, 2012.
-
Abstract
- Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.
- Subjects :
- animal diseases
viruses
Immunology
Central nervous system
Simian Acquired Immunodeficiency Syndrome
Biology
medicine.disease_cause
Microbiology
Virus
Pathogenesis
Immune system
Virology
medicine
Animals
virus diseases
Simian immunodeficiency virus
medicine.disease
medicine.anatomical_structure
Insect Science
Macaca
Pathogenesis and Immunity
Nervous System Diseases
Viral load
Meningitis
Encephalitis
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....29e7aecb3fe70d63f622e31f84247300