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Association Between Cannabis Use and Complications Related to Crohn’s Disease: A Retrospective Cohort Study
- Source :
- Digestive Diseases and Sciences. 64:2939-2944
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Crohn’s disease is an idiopathic inflammatory process that is occasionally associated with complications, which cause significant morbidity and mortality. The anti-inflammatory effect of cannabis in intestinal inflammation has been shown in several experimental models; it is unknown whether this correlates with fewer complications in Crohn’s disease patients. To compare the prevalence of Crohn’s disease-related complications among cannabis users and non-users in patients admitted with a primary diagnosis of Crohn’s disease or a primary diagnosis of Crohn’s related complication and a secondary diagnosis of Crohn’s disease between 2012 and 2014. We used data from the Healthcare Cost and Utilization Project–National Inpatient Sample. Cannabis users (615) were compared directly after propensity score match to non-users, in aspects of various complications and clinical end-points. Among matched cohorts, Cannabis users were less likely to have the following: active fistulizing disease and intra-abdominal abscess (11.5% vs. 15.9%; aOR 0.68 [0.49 to 0.94], p = 0.025), blood product transfusion (5.0% vs. 8.0%; aOR 0.48 [0.30 to 0.79], p = 0.037), colectomy (3.7% vs. 7.5%; aOR 0.48 [0.29–0.80], p = 0.004), and parenteral nutrition requirement (3.4% vs. 6.7%, aOR 0.39 [0.23 to 0.68], p = 0.009). Cannabis use may mitigate several of the well-described complications of Crohn’s disease among hospital inpatients. These effects could possibly be through the effect of cannabis in the endocannabinoid system.
- Subjects :
- Adult
Male
Marijuana Abuse
Parenteral Nutrition
medicine.medical_specialty
Abdominal Abscess
Physiology
medicine.medical_treatment
Disease
03 medical and health sciences
0302 clinical medicine
Crohn Disease
Internal medicine
Intestinal Fistula
Prevalence
medicine
Humans
Blood Transfusion
Correlation of Data
Propensity Score
Colectomy
Retrospective Studies
Crohn's disease
biology
business.industry
Gastroenterology
Retrospective cohort study
Middle Aged
medicine.disease
biology.organism_classification
United States
Parenteral nutrition
030220 oncology & carcinogenesis
Propensity score matching
Female
030211 gastroenterology & hepatology
Cannabis
business
Complication
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi.dedup.....29e03b58d173f8693c3ae8c24feda673