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Porous biodegradable EW62 medical implants resist tumor cell growth
- Source :
- Materials scienceengineering. C, Materials for biological applications. 61
- Publication Year :
- 2015
-
Abstract
- Magnesium alloys have been widely investigated for biodegradable medical applications. However, the shielding of harmful cells (eg. bacteria or tumorous cells) from immune surveillance may be compounded by the increased porosity of biodegradable materials. We previously demonstrated the improved corrosion resistance and mechanical properties of a novel EW62 (Mg-6%Nd-2%Y-0.5%Zr)) magnesium alloy by rapid solidification followed by extrusion (RS) compared to its conventional counterpart (CC). The present in vitro study evaluated the influence of rapid solidification on cytotoxicity to murine osteosarcoma cells. We found that CC and RS corrosion extracts significantly reduced cell viability over a 24-h exposure period. Cell density was reduced over 48 h following direct contact on both CC and RS surfaces, but was further reduced on the CC surface. The direct presence of cells accelerated corrosion for both materials. The corroded RS material exhibited superior mechanical properties relative to the CC material. The data show that the improved corrosion resistance of the rapidly solidified EW62 alloy (RS) resulted in a relatively reduced cytotoxic effect on tumorous cells. Hence, the tested alloy in the form of a rapidly solidified substance may introduce a good balance between its biodegradation characteristics and cytotoxic effect towards cancerous and normal cells.
- Subjects :
- 0301 basic medicine
Materials science
chemistry.chemical_element
Bioengineering
Bone Neoplasms
02 engineering and technology
Corrosion
Biomaterials
03 medical and health sciences
Mice
Cell Line, Tumor
Absorbable Implants
Alloys
Cytotoxic T cell
Animals
Magnesium
Viability assay
Magnesium alloy
Cytotoxicity
Osteosarcoma
Metallurgy
Biodegradation
021001 nanoscience & nanotechnology
030104 developmental biology
chemistry
Mechanics of Materials
Extrusion
0210 nano-technology
Porosity
Nuclear chemistry
Subjects
Details
- ISSN :
- 18730191
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Materials scienceengineering. C, Materials for biological applications
- Accession number :
- edsair.doi.dedup.....29d28ffcffa055b667b1cdfa30737392