Characterization of magnetic labels for bioassays

9 - conference paper: Seventh International Conference on the Scientific and Clinical Applications of Magnetic Carriers; 20-24 May 2008; Vancouver (Canada); Magnetic nanoparticles differing by their size have been synthesized to use them for multiparametric testing, based on their differing magnetic properties. The nanoparticle has two essential roles: to act as a probe owing to its specific magnetic properties and to carry on its surface precursor groups for the covalent coupling of biological recognition molecules, such as antibodies, nucleic acids. A totally unique, newly patented, method has been used to characterize magnetic signatures using the MIAplex technology. The MIAplex reader, developed by Magnisense, measures the non-linear response of the magnetic labels when they are exposed to a multi-frequency alternating magnetic field. This specific signature based on d2B(H)/dH2 was correlated to other more conventional magnetic detection methods (superconducting quantum interference devices (SQUID) and Mössbauer).