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Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction
- Source :
- Acta crystallographica Section F : Structural biology communications [2014-...], Acta crystallographica Section F : Structural biology communications [2014-..], 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta crystallographica. Section F, Structural biology communications, Acta crystallographica. Section F, Structural biology communications, John Wiley & Sons Ltd, 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta Crystallographica Section F Structural Biology Communications
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ.
- Subjects :
- In situ
Materials science
Microfluidics
Biophysics
MESH: crystallization
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry
Research Communications
law.invention
Crystal
X-Ray Diffraction
Structural Biology
law
Genetics
Crystallization
MESH: microfluidic
Diffractometer
[SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]
A protein
Biomolecules (q-bio.BM)
021001 nanoscience & nanotechnology
Condensed Matter Physics
0104 chemical sciences
MESH: crystallography
Quantitative Biology - Biomolecules
Chemical engineering
FOS: Biological sciences
X-ray crystallography
[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci]
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 2053230X
- Database :
- OpenAIRE
- Journal :
- Acta crystallographica Section F : Structural biology communications [2014-...], Acta crystallographica Section F : Structural biology communications [2014-..], 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta crystallographica. Section F, Structural biology communications, Acta crystallographica. Section F, Structural biology communications, John Wiley & Sons Ltd, 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta Crystallographica Section F Structural Biology Communications
- Accession number :
- edsair.doi.dedup.....29b765580ecefb1a7518a375abfdd948