Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

Authors :: Tiphaine Huet
Leonard M. G. Chavas
Nathalie Ferte
Charline J. J. Gerard
Romain Grossier
Nadine Candoni
Laurent Vuillard
Gilles Ferry
Stéphane Veesler
Jean A. Boutin
Centre Interdisciplinaire de Nanoscience de Marseille (CINaM)
Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Institut de Recherches Servier
Centre de Recherches de Croissy
Synchrotron SOLEIL (SSOLEIL)
Centre National de la Recherche Scientifique (CNRS)
Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Source :: Acta crystallographica Section F : Structural biology communications [2014-...], Acta crystallographica Section F : Structural biology communications [2014-..], 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta crystallographica. Section F, Structural biology communications, Acta crystallographica. Section F, Structural biology communications, John Wiley & Sons Ltd, 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta Crystallographica Section F Structural Biology Communications
Publication Year :: 2017
Publisher :: HAL CCSD, 2017.
Abstract: A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ.

Language :: English
ISSN :: 2053230X
Database :: OpenAIRE
Journal :: Acta crystallographica Section F : Structural biology communications [2014-...], Acta crystallographica Section F : Structural biology communications [2014-..], 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta crystallographica. Section F, Structural biology communications, Acta crystallographica. Section F, Structural biology communications, John Wiley & Sons Ltd, 2017, 73 (10), pp.574-578. ⟨10.1107/S2053230X17013826⟩, Acta Crystallographica Section F Structural Biology Communications
Accession number :: edsair.doi.dedup.....29b765580ecefb1a7518a375abfdd948

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