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Enhancement of IL-6 receptor β chain (gp130) expression by IL-6, IL-1 and TNF in human epithelial cells
- Source :
- Biochemical and Biophysical Research Communications. 185:902-908
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- Analysis of the IL-6 Receptor β chain (gp130) mRNA expression on the two human epithelial cell lines UAC and Hep3B reveals that it is enhanced by IL-6, IL-1 and TNF treatment. In the case of UAC cells, TNF action might be mediated by IL-6. For Hep3B cells, TNF seems to exert a direct effect on gp130, as no IL-6 expression is detected after stimulation by this cytokine. On the same cells, increase of the binding of an anti-gp130 monoclonal antibody was observed after treatment by TNF, which denotes the effective appearance of new gp130 molecules on the cell surface. All this cytokines seem to act selectively on the β chain of the IL-6 receptor. This probably reflects the importance for some cells to have gp130 represented on their membrane in inflammatory contexts.
- Subjects :
- medicine.medical_specialty
Carcinoma, Hepatocellular
Macromolecular Substances
medicine.medical_treatment
Molecular Sequence Data
Cell
Biophysics
Gene Expression
Biology
Biochemistry
Epithelium
Cell Line
Cell surface receptor
Internal medicine
medicine
Humans
Amnion
RNA, Messenger
Receptors, Immunologic
Receptor
Molecular Biology
Base Sequence
Interleukin-6
Tumor Necrosis Factor-alpha
Liver Neoplasms
digestive, oral, and skin physiology
Cell Biology
Blotting, Northern
Glycoprotein 130
Receptors, Interleukin-6
Molecular biology
Recombinant Proteins
medicine.anatomical_structure
Endocrinology
Cytokine
Oligodeoxyribonucleotides
Cell culture
Interleukin-6 receptor
RNA
Tumor necrosis factor alpha
DNA Probes
Interleukin-1
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 185
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....29b742f0209aa614ad1851b27171147d