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Neuronal Architecture of a Visual Center that Processes Optic Flow
- Source :
- Neuron
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Animals use global image motion cues to actively stabilize their position by compensatory movements. Neurons in the zebrafish pretectum distinguish different optic flow patterns, e.g., rotation and translation, to drive appropriate behaviors. Combining functional imaging and morphological reconstruction of single cells, we revealed critical neuroanatomical features of this sensorimotor transformation. Terminals of direction-selective retinal ganglion cells (DS-RGCs) are located within the pretectal retinal arborization field 5 (AF5), where they meet dendrites of pretectal neurons with simple tuning to monocular optic flow. Translation-selective neurons, which respond selectively to optic flow in the same direction for both eyes, are intermingled with these simple cells but do not receive inputs from DS-RGCs. Mutually exclusive populations of pretectal projection neurons innervate either the reticular formation or the cerebellum, which in turn control motor responses. We posit that local computations in a defined pretectal circuit transform optic flow signals into neural commands driving optomotor behavior. VIDEO ABSTRACT.
- Subjects :
- Retinal Ganglion Cells
0301 basic medicine
Superior Colliculi
Cerebellum
Neuropil
genetic structures
Computer science
Presynaptic Terminals
Optic Flow
Reticular formation
Retinal ganglion
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Vision, Monocular
medicine
Animals
Visual Pathways
Pretectal area
Zebrafish
Vision, Binocular
Monocular
Reticular Formation
General Neuroscience
Retinal
Dendrites
eye diseases
Functional imaging
030104 developmental biology
medicine.anatomical_structure
chemistry
Optomotor response
sense organs
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....29b4f13c11258fa241aee027b5b812e9