Back to Search
Start Over
Plasma metanephrine for assessing the selectivity of adrenal venous sampling
- Source :
- Hypertension, 62, 1152-7, Hypertension, 62, 6, pp. 1152-7
- Publication Year :
- 2013
- Publisher :
- Bioscientifica, 2013.
-
Abstract
- Adrenal vein sampling is used to establish the origins of excess production of adrenal hormones in primary aldosteronism. Correct catheter positioning is confirmed using adrenal vein measurements of cortisol, but this parameter is not always reliable. Plasma metanephrine represents an alternative parameter. The objective of our study was to determine the use of plasma metanephrine concentrations to establish correct catheter positioning during adrenal vein sampling with and without cosyntropin stimulation. We included 52 cosyntropin-stimulated and 34 nonstimulated sequential procedures. Plasma cortisol and metanephrine concentrations were measured in adrenal and peripheral venous samples. Success rates of sampling, using an adrenal to peripheral cortisol selectivity index of 3.0, were compared with success rates of metanephrine using a selectivity index determined by receiver operating characteristic curve analysis. Among procedures assessed as selective using cortisol, the adrenal to peripheral vein ratio of metanephrine was 6-fold higher than that of cortisol (94.0 versus 15.5; P P
- Subjects :
- Adult
Male
medicine.medical_specialty
Hydrocortisone
Urology
Veins
chemistry.chemical_compound
Primary aldosteronism
Cosyntropin
Internal medicine
Adrenal Glands
Hyperaldosteronism
Internal Medicine
medicine
Humans
Vein
Aldosterone
Metanephrine
Aged
Blood Specimen Collection
Cardiovascular diseases [NCEBP 14]
Receiver operating characteristic
business.industry
Chemistry
Hormonal regulation [IGMD 6]
Middle Aged
medicine.disease
Adrenal venous sampling
Peripheral
Endocrinology
medicine.anatomical_structure
Hormonal regulation Aetiology, screening and detection [IGMD 6]
Female
business
Selectivity
Subjects
Details
- ISSN :
- 14796848 and 0194911X
- Database :
- OpenAIRE
- Journal :
- Endocrine Abstracts
- Accession number :
- edsair.doi.dedup.....29b4bb8f2f2d58807958ad2493bb3839