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Immunohistochemical localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp
Immunohistochemical localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp
- Source :
- Anatomy and embryology. 183(5)
- Publication Year :
- 1991
-
Abstract
- The distribution in oral tissues of endothelin, a multifunctional peptide originally identified within endothelial cells, and subsequently in some epithelial cells, neurons and neuroendocrine cells, has not been investigated yet. We have studied the localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp by immunohistochemical techniques. Such immunoreactivity was detected only within endothelial cells in both mature dental pulp and developing tooth. Arteries and veins of various sizes as well as small thin vessels displayed endothelin-like immunoreactivity. In the tooth germ, the cells of the enamel organ or the precursors of the odontoblasts were found unreactive. In the mature pulp, no cells of the stroma or nerves displayed endothelin-like immunoreactivity. These findings suggest that vascular endothelium may be the only source of endothelin in human dental tissues. It is tentatively proposed that endothelin released in mature tooth pulp may participate in the regulation of the pulpal blood flow. Although the possible role of endothelin in developing tissues is far from being clear, the mitogenic effects and the proto-oncogenes expression induced by endothelin in some cells raise the possibility that this peptide might also play a role during tooth development.
- Subjects :
- Adult
Embryology
Pathology
medicine.medical_specialty
Immunocytochemistry
Fluorescent Antibody Technique
Biology
Immunoenzyme Techniques
Fetus
stomatognathic system
Stroma
Human tooth
medicine
Humans
Tissue Distribution
Dental Pulp
Endothelins
Enamel organ
Tooth Germ
Cell Biology
stomatognathic diseases
medicine.anatomical_structure
Odontoblast
cardiovascular system
Pulp (tooth)
Immunohistochemistry
Anatomy
Endothelin receptor
Developmental Biology
Subjects
Details
- ISSN :
- 03402061
- Volume :
- 183
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Anatomy and embryology
- Accession number :
- edsair.doi.dedup.....29a591154cf402666897c5ae69f50ef1