Back to Search
Start Over
The Disappearance of Subpleural and Interlobular Lymphatics in Idiopathic Pulmonary Fibrosis
- Source :
- Lymphatic Research and Biology. 8:199-207
- Publication Year :
- 2010
- Publisher :
- Mary Ann Liebert Inc, 2010.
-
Abstract
- The lymphatics in the interlobular and subpleural parenchyma contribute to alveolar clearance in the lung, but the information on the remodeling of these lymphatics is quite limited in idiopathic pulmonary fibrosis lungs that contain severe fibrosis in these regions. We compared the alteration of these lymphatics and lymphangiogenesis among idiopathic pulmonary fibrosis and nonfibrotic interstitial pneumonias with a better prognosis.The lung tissue specimens of eighteen patients with idiopathic pulmonary fibrosis (ten surgical biopsies and eight autopsies), six with organizing pneumonia, six with cellular nonspecific interstitial pneumonia, and five normal controls were examined by morphometric analysis of the lymphatics identified by immunohistochemistry. In addition, three-dimensional reconstruction of lymphatics, apoptosis of lymphatic endothelial cells and the cells producing growth factors for lymphangiogenesis were also evaluated. Both the subpleural and the interlobular lymphatics in idiopathic pulmonary fibrosis lungs were significantly decreased in the severe fibroconnective lesions, with rare lymphangiogenesis. The three-dimensional images of the subpleural lymphatics in idiopathic pulmonary fibrosis clearly revealed destruction by fibrosis; apoptosis was observed in these lymphatic endothelial cells. In contrast, organizing pneumonia and cellular nonspecific interstitial pneumonia preserved these lymphatics, and active lymphangiogenesis occurred in the alveolar lesions.These results reveal severe damage of the subpleural and interlobular lymphatics in idiopathic pulmonary fibrosis lungs, and suggest impaired alveolar clearance as another pathogenesis of its refractoriness.
- Subjects :
- Male
Pathology
medicine.medical_specialty
government.form_of_government
Apoptosis
Idiopathic pulmonary fibrosis
Imaging, Three-Dimensional
Parenchyma
medicine
Humans
Lymphangiogenesis
Aged
Lymphatic Vessels
Lung
business.industry
Endothelial Cells
Middle Aged
medicine.disease
Immunohistochemistry
Idiopathic Pulmonary Fibrosis
Pulmonary Alveoli
Lymphatic Endothelium
Lymphatic system
medicine.anatomical_structure
government
Female
Lung Diseases, Interstitial
Cardiology and Cardiovascular Medicine
Lung tissue
business
Subjects
Details
- ISSN :
- 15578585 and 15396851
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Lymphatic Research and Biology
- Accession number :
- edsair.doi.dedup.....299713bca3079bee1b2dd13ed4f34017