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Characterisation of white matter asymmetries in the healthy human brain using diffusion MRI fixel-based analysis
Characterisation of white matter asymmetries in the healthy human brain using diffusion MRI fixel-based analysis
- Source :
- NeuroImage, Vol 225, Iss, Pp 117505-(2021)
- Publication Year :
- 2020
-
Abstract
- The diffusion tensor model for diffusion MRI has been used extensively to study asymmetry in the human brain white matter. However, given the limitations of the tensor model, the nature of any underlying asymmetries remains uncertain, particularly in crossing fibre regions. Here, we provide a more robust characterisation of human brain white matter asymmetries based on fibre-specific diffusion MRI metrics and a whole-brain data-driven approach. We used high-quality diffusion MRI data (n = 100) from the Human Connectome Project, the spherical deconvolution model for fibre orientation distribution estimation, and the Fixel-Based Analysis framework to utilise crossing fibre information in registration, data smoothing and statistical inference. We found many significant asymmetries, widespread throughout the brain white matter, with both left>right and right>left dominances observed in different pathways. No influences of sex, age, or handedness on asymmetry were found. We also report on the relative contributions of microstructural and morphological white matter properties toward the asymmetry findings. Our findings should provide important information to future studies focussing on how these asymmetries are affected by disease, development/ageing, or how they correlate to functional/cognitive measures.
- Subjects :
- Fixel-based analysis
Adult
Male
Cognitive Neuroscience
media_common.quotation_subject
Asymmetry
050105 experimental psychology
Functional Laterality
Diffusion MRI
lcsh:RC321-571
White matter
03 medical and health sciences
Young Adult
0302 clinical medicine
Sex Factors
medicine
Statistical inference
Connectome
Image Processing, Computer-Assisted
Humans
0501 psychology and cognitive sciences
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
media_common
Mathematics
Human Connectome Project
Orientation (computer vision)
05 social sciences
Age Factors
Brain
Human brain
White Matter
Healthy Volunteers
medicine.anatomical_structure
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Neurology
Female
Neuroscience
030217 neurology & neurosurgery
Smoothing
Subjects
Details
- ISSN :
- 10959572
- Volume :
- 225
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....2990e17439ce0f9ae70476c00eb7fb24