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Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer
- Source :
- BMC Clinical Pathology, Vol 17, Iss 1, Pp 1-10 (2017), BMC Clinical Pathology, Latif, A, Chadwick, A L, Kitson, S J, Gregson, H J, Sivalingam, V N, Bolton, J, McVey, R J, Roberts, S A, Marshall, K M, Williams, K J, Stratford, I J & Crosbie, E J 2017, ' Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer ', BMC Clinical Pathology, vol. 17, pp. 27 . https://doi.org/10.1186/s12907-017-0067-7
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Background Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered energy metabolism is a hallmark of malignancy. Cancer cells drive tumour growth through aerobic glycolysis and must export lactate to maintain intracellular pH. The aim of this study was to evaluate the expression of the lactate/proton monocarboxylate transporters MCT1 and MCT4 and their chaperone CD147 in EC, with the ultimate aim of directing future drug development. Methods MCT1, MCT4 and CD147 expression was examined using immunohistochemical analysis in 90 endometrial tumours and correlated with clinico-pathological characteristics and survival outcomes. Results MCT1 and MCT4 expression was observed in the cytoplasm, the plasma membrane or both locations. CD147 was detected in the plasma membrane and associated with MCT1 (p = 0.003) but not with MCT4 (p = 0.207) expression. High MCT1 expression was associated with reduced overall survival (p = 0.029) and remained statistically significant after adjustment for survival covariates (p = 0.017). Conclusion Our data suggest that MCT1 expression is an important marker of poor prognosis in EC. MCT1 inhibition may have potential as a treatment for advanced or recurrent EC. Electronic supplementary material The online version of this article (10.1186/s12907-017-0067-7) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
Histology
Intracellular pH
Malignancy
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Endometrial cancer
medicine
lcsh:Pathology
Glycolysis
Monocarboxylate transporters
Hypoxia
biology
business.industry
medicine.disease
3. Good health
030104 developmental biology
Monocarboxylate transporter 1
Anaerobic glycolysis
030220 oncology & carcinogenesis
Cancer cell
Cancer research
biology.protein
Immunohistochemistry
business
Research Article
lcsh:RB1-214
Subjects
Details
- Language :
- English
- ISSN :
- 14726890
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Clinical Pathology
- Accession number :
- edsair.doi.dedup.....2988b7c7ec7d61abc52b001e69a8d9ac