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Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The remarkable heterogeneity of glioblastoma, across patients and over time, is one of the main challenges in precision diagnostics and treatment planning. Non-invasive in vivo characterization of this heterogeneity using imaging could assist in understanding disease subtypes, as well as in risk-stratification and treatment planning of glioblastoma. The current study leveraged advanced imaging analytics and radiomic approaches applied to multi-parametric MRI of de novo glioblastoma patients (n = 208 discovery, n = 53 replication), and discovered three distinct and reproducible imaging subtypes of glioblastoma, with differential clinical outcome and underlying molecular characteristics, including isocitrate dehydrogenase-1 (IDH1), O6-methylguanine–DNA methyltransferase, epidermal growth factor receptor variant III (EGFRvIII), and transcriptomic subtype composition. The subtypes provided risk-stratification substantially beyond that provided by WHO classifications. Within IDH1-wildtype tumors, our subtypes revealed different survival (p EGFRvIII-mutated tumors. The identified subtypes and their clinical and molecular correlates provide an in vivo portrait of phenotypic heterogeneity in glioblastoma, which points to the need for precision diagnostics and personalized treatment.
- Subjects :
- Male
Oncology
medicine.medical_specialty
IDH1
lcsh:Medicine
Disease
Article
Transcriptome
O(6)-Methylguanine-DNA Methyltransferase
03 medical and health sciences
0302 clinical medicine
In vivo
Internal medicine
Humans
Medicine
Epidermal growth factor receptor
lcsh:Science
Radiation treatment planning
Survival analysis
Multidisciplinary
biology
Brain Neoplasms
business.industry
Genetic heterogeneity
lcsh:R
Brain
Prognosis
Magnetic Resonance Imaging
Survival Analysis
Isocitrate Dehydrogenase
3. Good health
ErbB Receptors
030220 oncology & carcinogenesis
biology.protein
Female
lcsh:Q
Glioblastoma
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....2988ac3537ab39d3b843c791bb225d30