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Single-strand binding protein enhances invasion of a PNA strand to double-stranded DNA
- Source :
- Scopus-Elsevier
- Publication Year :
- 2008
- Publisher :
- Oxford University Press (OUP), 2008.
-
Abstract
- We show that, in the presence of single-strand binding protein (SSB), one strand of peptide nucleic acid (PNA) efficiently invades double-stranded DNA (dsDNA) in sequence-specific manner, as shown in Figure 1. In the absence of SSB, this kind of strand invasion never occurs. This significant enhancement of invasion can be applied to in vivo applications.
- Subjects :
- Peptide Nucleic Acids
biology
Peptide nucleic acid
Chemistry
Binding protein
DNA
General Medicine
Single-stranded binding protein
DNA-Binding Proteins
stomatognathic diseases
chemistry.chemical_compound
In vivo
Coding strand
biology.protein
Biophysics
Replisome
Strand invasion
skin and connective tissue diseases
Subjects
Details
- ISSN :
- 17468272 and 02613166
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Symposium Series
- Accession number :
- edsair.doi.dedup.....2984283425314ab871c99ad47fa17bc9