Back to Search
Start Over
Adverse reactions to BNT162b2 mRNA COVID-19 vaccine in medical staff with a history of allergy
- Source :
- Respiratory Investigation
- Publication Year :
- 2021
- Publisher :
- Published by Elsevier B.V. on behalf of The Japanese Respiratory Society., 2021.
-
Abstract
- Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) vaccination is progressing globally. Several adverse reactions have been reported with vaccination against COVID-19. It is unknown whether adverse reactions to COVID-19 vaccination are severe in individuals with allergies. Methods We administered the COVID-19 vaccine to the medical staff at Yamagata University Hospital from March to August 2021. Subsequently, we conducted an online questionnaire-based survey to investigate the presence of allergy and adverse reactions after vaccination and examine the association between allergy and adverse reactions after immunization. Results Responses were collected from 1586 and 1306 participants after the first and second administration of the BNT162b2 mRNA COVID-19 vaccine, respectively. Adverse reactions included injection site pain, injection site swelling, fever, fatigue or malaise, headache, chills, nausea, muscle pain outside the injection site, and arthralgia. The frequency of some adverse reactions and their severity were higher, and the duration of symptoms was longer in participants with allergies than in those without allergies. Although several participants visited the emergency room for treatment after the first and second vaccinations, no participant was diagnosed with anaphylaxis. Conclusions This study suggests that the frequency and severity of adverse reactions after injection of BNT162b2 mRNA COVID-19 vaccine were higher in individuals with allergy; however, no severe adverse reactions such as anaphylaxis or death were observed. These results indicate that individuals with allergic histories may tolerate the BNT162b2 mRNA COVID-19 vaccine.
- Subjects :
- Pulmonary and Respiratory Medicine
COVID-19 Vaccines
SARS-CoV-2
healthcare workers
mRNA, messenger ribonucleic acid
adverse reaction
COVID-19
BNT162b2 mRNA COVID-19 vaccine
allergy
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
Medical Staff
Humans
Original Article
RNA, Messenger
JAK, Janus kinase
Anaphylaxis
BNT162 Vaccine
severe acute respiratory syndrome coronavirus 2
COVID-19, coronavirus disease 2019
Subjects
Details
- Language :
- English
- ISSN :
- 22125353 and 22125345
- Database :
- OpenAIRE
- Journal :
- Respiratory Investigation
- Accession number :
- edsair.doi.dedup.....2980848562d1a0ed1622be7ab71e71a8