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Clinical impact of human metapneumovirus infections before and during the COVID-19 pandemic
- Source :
- Infectious Diseases, 53(7), 488-497. Taylor & Francis Ltd
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Background: The first outbreak of coronavirus disease 2019 (COVID-19) occurred in March 2020 in Europe, which is normally the peak incidence period of human metapneumovirus (HMPV) infections, implying cocirculation and potentially causing competition between them. Methods: We investigated differences in clinical characteristics and outcomes of HMPV infections in hospitalized patients before (January 2016–28 February, 2020) and HMPV and COVID-19 during part of the COVID-19 pandemic (28 February, 2020–1 April, 2020). Results: A total of 239 HMPV patients and 303 COVID-19 patients were included. Incidence of HMPV peaked in March. Despite a 324% increase in HMPV testing during the COVID-19 outbreak, incidence of HMPV remained stable. Clinical characteristics showed 25 (11%) ICU admissions and 14 (6%) deaths. History of myocardial infarction, higher age and lower BMI were independently associated with increased 30-day mortality. Clinical characteristics of HMPV-infected patients did not differ between the non-COVID-19 period and the examined COVID-19 period except for length of hospital stay (7 vs. 5 days). HMPV infection and COVID-19 shared many clinical features but HMPV was associated with female gender, elderly patients and chronic conditions (COPD and chronic heart failure). Clinical outcomes did not differ between the viruses during the COVID-19 period. Conclusions: The clinical impact of HMPV infection did not change during the COVID-19 outbreak in terms of incidence and/or disease severity; hence, HMPV and SARS-CoV-2 are probably co-circulating independently. Despite the current clinical focus on the COVID-19 pandemic, clinicians should keep in mind that HMPV-infection may mimic COVID-19 and is also associated with serious adverse outcomes.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030106 microbiology
03 medical and health sciences
0302 clinical medicine
SDG 3 - Good Health and Well-being
Human metapneumovirus
Pandemic
Humans
Medicine
Metapneumovirus
030212 general & internal medicine
Pandemics
Respiratory Tract Infections
Aged
Paramyxoviridae Infections
General Immunology and Microbiology
biology
SARS-CoV-2
business.industry
Incidence (epidemiology)
COVID-19
Infant
virus diseases
Outbreak
General Medicine
biology.organism_classification
Virology
respiratory tract diseases
Europe
Infectious Diseases
Female
business
Subjects
Details
- ISSN :
- 23744243 and 23744235
- Database :
- OpenAIRE
- Journal :
- Infectious Diseases
- Accession number :
- edsair.doi.dedup.....297e7f3765b2032310d4b9ea16d665b6
- Full Text :
- https://doi.org/10.1080/23744235.2021.1887510