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Abdominal symptoms in cystic fibrosis and their relation to genotype, history, clinical and laboratory findings
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 5, p e0174463 (2017)
- Publication Year :
- 2016
-
Abstract
- Background & aims Abdominal symptoms (AS) are a hallmark of the multiorgan-disease cystic fibrosis (CF). However, the abdominal involvement in CF is insufficiently understood and, compared to the pulmonary manifestation, still receives little scientific attention. Aims were to assess and quantify AS and to relate them to laboratory parameters, clinical findings, and medical history. Methods A total of 131 patients with CF of all ages were assessed with a new CF-specific questionnaire (JenAbdomen-CF score 1.0) on abdominal pain and non-pain symptoms, disorders of appetite, eating, and bowel movements as well as symptom-related quality of life. Results were metrically dimensioned and related to abdominal manifestations, history of surgery, P. aeruginosa and S. aureus colonization, genotype, liver enzymes, antibiotic therapy, lung function, and nutritional status. Results AS during the preceding 3 months were reported by all of our patients. Most common were lack of appetite (130/131) and loss of taste (119/131) followed by abdominal pain (104/131), flatulence (102/131), and distention (83/131). Significantly increased AS were found in patients with history of rectal prolapse (p = 0.013), distal intestinal obstruction syndrome (p = 0.013), laparotomy (p = 0.022), meconium ileus (p = 0.037), pancreas insufficiency (p = 0.042), or small bowel resection (p = 0.048) as well as in patients who have been intermittently colonized with P. aeruginosa (p = 0.006) compared to patients without history of these events. In contrast, no statistically significant associations were found to CF-associated liver disease, chronic pathogen colonization, lung function, CF-related diabetes, and nutritional status. Conclusion As the complex abdominal involvement in CF is still not fully understood, the assessment of the common AS is of major interest. In this regard, symptom questionnaires like the herein presented are meaningful and practical tools facilitating a wider understanding of the abdominal symptoms in CF. Furthermore, they render to evaluate possible abdominal effects of novel modulators of the underlying cystic fibrosis transmembrane (conductance) regulator (CFTR) defect.
- Subjects :
- Male
Questionnaires
Abdominal pain
Cystic Fibrosis
Pulmonology
medicine.medical_treatment
lcsh:Medicine
Cystic Fibrosis Transmembrane Conductance Regulator
Pathology and Laboratory Medicine
Cystic fibrosis
Gastroenterology
Liver disease
0302 clinical medicine
Antibiotics
Laparotomy
Abdomen
Medicine and Health Sciences
030212 general & internal medicine
lcsh:Science
Child
Multidisciplinary
Antimicrobials
Drugs
Pseudomonas Aeruginosa
Bacterial Pathogens
medicine.anatomical_structure
Genetic Diseases
Research Design
Medical Microbiology
Child, Preschool
Female
Radiology
medicine.symptom
Anatomy
Pathogens
Research Article
medicine.medical_specialty
Adolescent
Genotype
Meconium Ileus
Pain
Research and Analysis Methods
Microbiology
03 medical and health sciences
Signs and Symptoms
Autosomal Recessive Diseases
Diagnostic Medicine
Internal medicine
Microbial Control
Pseudomonas
medicine
Humans
Medical history
Microbial Pathogens
Nutrition
Clinical Genetics
Pharmacology
Survey Research
Bacteria
business.industry
lcsh:R
Infant, Newborn
Organisms
Infant
Biology and Life Sciences
medicine.disease
Fibrosis
Abdominal Pain
Distal intestinal obstruction syndrome
Gastrointestinal Tract
030228 respiratory system
lcsh:Q
business
Digestive System
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....297aabf8ab3910eedbd86e3db034a85a