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Behavioural and epigenetic effects of paternal exposure to cannabinoids during adolescence on offspring vulnerability to stress
- Source :
- International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 72
- Publication Year :
- 2018
-
Abstract
- Chronic cannabinoid exposure during adolescence in male rats induces chronic cognitive and emotional impairments. However, the impact of this form of exposure on offspring vulnerability to stress is unknown. The aim of this study was to evaluate the behavioural and epigenetic effects of stress in the offspring of male rats whose fathers were exposed to cannabinoids during adolescence. Male adolescent offspring of Win55,212-2 (1.2 mg/kg) treated rats were exposed during one week to variable stressors and subjected to behavioural tests of anxiety and episodic-like memory, followed by an assessment of global DNA methylation and expression of DNA methyltransferases enzymes DNMT1 and DNMT3a mRNA in the prefrontal cortex. Stress exposure induced a significant anxiogenic-like effect but did not affect the episodic-like memory in the offspring of Win55,212-2 exposed fathers in comparison to the offspring of non-exposed fathers. These behavioural changes were subsequent to a significant increase in global DNA methylation and DNMT1 and DNMTa3 transcription in the prefrontal cortex. These data suggest that the deleterious effect of chronic exposure to cannabinoids during adolescence are not limited to the exposed individuals but may increase the vulnerability to stress-induced anxiety in the offspring and alter their epigenetic programming.
- Subjects :
- DNA (Cytosine-5-)-Methyltransferase 1
Male
Methyltransferase
Offspring
Morpholines
Physiology
Biology
Naphthalenes
DNA Methyltransferase 3A
03 medical and health sciences
0302 clinical medicine
Developmental Neuroscience
Pregnancy
medicine
Animals
Epigenetics
DNA (Cytosine-5-)-Methyltransferases
Rats, Wistar
Prefrontal cortex
030304 developmental biology
0303 health sciences
Cannabinoids
Stressor
Recognition, Psychology
DNA Methylation
Calcium Channel Blockers
Benzoxazines
Rats
Paternal Exposure
Animals, Newborn
Gene Expression Regulation
Prenatal Exposure Delayed Effects
DNA methylation
Exploratory Behavior
Anxiety
Female
medicine.symptom
Corticosterone
030217 neurology & neurosurgery
Locomotion
Stress, Psychological
Developmental Biology
Subjects
Details
- ISSN :
- 1873474X
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
- Accession number :
- edsair.doi.dedup.....295a32906f25da762806e11b068aaa13