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Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis
- Source :
- Microbial pathogenesis. 129
- Publication Year :
- 2018
-
Abstract
- Toxoplasmosis, caused by Toxoplasma gondii, is a great public health concern in cancer patients, which can induce serious pathological effects. This systematic review and meta-analysis was performed to evaluate the worldwide seroprevalence rate of T. gondii infection among cancer patients. A search was conducted on five electronic databases that reported data on T. gondii seroprevalence in cancer patients. The searching process resulted in the inclusion of 57 studies. The results showed that T. gondii had the pooled prevalence of 30.8% in cancer patients using a random-effect model (95% CI: 26.3-35.6). Cancer patients had a higher overall prevalence of T. gondii infection, compared to those without cancer. Furthermore, the odds ratio of toxoplasmosis in cancer patients was 3.1 times, compared to that of controls (95% CI: 2.5-3.8, P 0.0001). Toxoplasmosis had a higher prevalence in females (40%) than in males (33%). Furthermore, the age group of upper 40 years had the highest prevalence infection rate (30%). In addition, a significant association was also observed between toxoplasmosis infection and year (P 0.001), type of cancer (P 0.001), country (P 0.001), gender (P 0.001), age (P = 0.006) and diagnostic method (P 0.001) in cancer patients. Considering the high prevalence of T. gondii infection in cancer patients and its serious outcomes, the researchers are suggested to carry out further studies to prevent and control toxoplasmosis among this population.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Adolescent
030106 microbiology
Antibodies, Protozoan
Global Health
Microbiology
03 medical and health sciences
Young Adult
Sex Factors
Risk Factors
Seroepidemiologic Studies
Internal medicine
Neoplasms
parasitic diseases
Epidemiology
medicine
Seroprevalence
Humans
Aged
Aged, 80 and over
biology
business.industry
Public health
Age Factors
Toxoplasma gondii
Cancer
Odds ratio
Middle Aged
biology.organism_classification
medicine.disease
Toxoplasmosis
030104 developmental biology
Infectious Diseases
Meta-analysis
Female
business
Toxoplasma
Subjects
Details
- ISSN :
- 10961208
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Microbial pathogenesis
- Accession number :
- edsair.doi.dedup.....2953ad09dc4421376eb98b07d5f559cd