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Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid‐childhood executive function and behaviour
- Source :
- Paediatr Perinat Epidemiol, Paediatric and Perinatal Epidemiology, 34(3), 287-298. Wiley-Blackwell Publishing Ltd
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- BACKGROUND: Over-the-counter analgesics during pregnancy or infancy may be related to neurobehavoiural problems in children, but little is known about effects of different analgesic types, dosage, and timing. OBJECTIVES: Examine associations of acetaminophen and ibuprofen use during pregnancy and infancy with executive function and behaviour problems in children. METHODS: We included 1225 mother-child pairs from Project Viva, a pre-birth cohort study. We assessed prenatal acetaminophen and ibuprofen use in early and mid-pregnancy and infant use in the first-year of life using questionnaires. Parents and classroom teachers assessed child behaviours in mid-childhood (median 8 years), using the Behavoiur Rating Inventory of Executive Function (BRIEF) and the Strengths and Difficulties Questionnaire (SDQ), with higher scores indicating worse functioning for both. We examined associations of acetaminophen and ibuprofen use during pregnancy and infancy with mid-childhood neurobehavoiural outcomes using linear regression models adjusted for potential confounders. RESULTS: During pregnancy, 46.1% of mothers used acetaminophen ≥10 times and 18.4% used any ibuprofen. In the first year, 65.3% and 39.6% of infants received acetaminophen and ibuprofen ≥6 times, respectively. Higher (≥10 versus
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Epidemiology
Analgesic
Child Behavior
Gestational Age
Ibuprofen
Nonprescription Drugs
Child Behavior Disorders
Article
Cohort Studies
Executive Function
03 medical and health sciences
Cognition
Child Development
0302 clinical medicine
Pregnancy
Humans
Medicine
030212 general & internal medicine
Child
Acetaminophen
030219 obstetrics & reproductive medicine
business.industry
organic chemicals
Age Factors
Infant
Infant exposure
Strengths and Difficulties Questionnaire
Analgesics, Non-Narcotic
medicine.disease
United States
Confidence interval
Pregnancy Complications
Behavior Rating Inventory of Executive Function
Neurodevelopmental Disorders
Child, Preschool
Prenatal Exposure Delayed Effects
Pediatrics, Perinatology and Child Health
Female
Pregnancy Trimesters
business
Brazil
Cohort study
medicine.drug
Subjects
Details
- ISSN :
- 13653016 and 02695022
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Paediatric and Perinatal Epidemiology
- Accession number :
- edsair.doi.dedup.....293e068bd13d7bc0e805c65aadc91b5f